HAMAP rule MF_01238
General rule information
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| Accession | MF_01238 |
| Dates | 29-APR-2003 (Created)
1-JUN-2023 (Last updated, Version 30) |
| Name | MFS_NanT |
| Scope(s) |
Bacteria Enterobacterales |
| Template(s) | P41036 (NANT_ECOLI); [ Recover all ] |
| Triggered by |
HAMAP; MF_01238 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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| Identifier | NANT |
| Protein name | RecName: Full=Sialic acid transporter NanT; AltName: Full=Sialic acid permease; AltName: Full=Sialic acid/H(+) symporter; |
| Gene name | Name=nanT; |
Comments
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| FUNCTION | Catalyzes the proton-dependent transport of sialic acid. |
| CATALYTIC ACTIVITY | Reaction=H(+)(in) + N-acetylneuraminate(in) = H(+)(out) + N- acetylneuraminate(out); Xref=Rhea:RHEA:28987, ChEBI:CHEBI:15378, ChEBI:CHEBI:35418; |
| SUBCELLULAR LOCATION | Cell inner membrane; Multi-pass membrane protein. |
| SIMILARITY | Belongs to the major facilitator superfamily. Sialate:H(+) symporter (SHS) (TC 2.A.1.12) family. |
Keywords
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| Transport |
| Sugar transport |
| Transmembrane |
| Membrane |
| Cell membrane |
| Cell inner membrane |
| Transmembrane helix |
Gene Ontology
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| GO:0015538; Molecular function:sialic acid:proton symporter activity |
| GO:0015739; Biological process:sialic acid transport |
| GO:0005886; Cellular component:plasma membrane |
Cross-references
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| Pfam | PF07690; MFS_1; 1; |
| NCBIfam | TIGR00891; 2A0112; 1; |
| PROSITE | PS50850; MFS; 1; |
| PROSITE | PS00216; SUGAR_TRANSPORT_1; 1; |
| PROSITE | PS00217; SUGAR_TRANSPORT_2; 1; |
| General | Transmembrane; -; 12-14; |
Features
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Additional information
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| Size range | 480-515 amino acids |
| Related rules |
None |
| Fusion | Nter: None Cter: None |
| Comments | Possible wrong start in the second copy in ECOL6 |