HAMAP

Accession	MF_01242
Dates	23-MAY-2003 (Created) 22-OCT-2010 (Last updated, Version 11)

Data class

Protein

Predictors

HAMAP; MF_01242; [distribution of match scores in UniProtKB];[seed alignment for MF_01242]

Names

Aliphatic_amidase

Identifier

AMIE

Protein name

RecName: Full=Aliphatic amidase; EC=3.5.1.4; AltName: Full=Acylamide amidohydrolase;

Gene name

amiE

FUNCTION: Catalyzes the hydrolysis of short-chain aliphatic amides to their corresponding organic acids with release of ammonia (By similarity).

FUNCTION: Also exhibits in vitro acyl transferase activity, transferring the acyl moiety of short-chain amides to hydroxylamine to form hydroxamates (By similarity).

CATALYTIC ACTIVITY: A monocarboxylic acid amide + H(2)O = a monocarboxylate + NH(3).

SIMILARITY: Belongs to the nitrilase superfamily. Aliphatic amidase family.

SIMILARITY: Contains 1 CN hydrolase domain.

Pfam	PF00795; CN_hydrolase; 1;
PROSITE	PS50263; CN_HYDROLASE; 1; trigger=PRU00054;

Hydrolase.

GO:0004040; Molecular function: amidase activity.

From: AMIE_PSEAE (P11436)
Key		From		To		Description		Condition		FTGroup
ACT_SITE		59		59		Proton acceptor (Potential)		E
ACT_SITE		134		134		Potential		K
ACT_SITE		166		166		Nucleophile (By similarity)		C

Size range:	339-348 amino acids
Related UniRules:	MF_01243 (AMIF)
Template:	Q9L543 (AMIE_BACSP); Q9RQ17 (AMIE_GEOSE); O25067 (AMIE_HELPY); P11436 (AMIE_PSEAE); Q01360 (AMIE_RHOER): [Recover all]
Scope:	Bacteria
Fusion:	Nter: None; Cter: None
Duplicate:	None
Plasmid encoded:	None