HAMAP

Accession	MF_01247
Dates	6-APR-2004 (Created) 13-SEP-2010 (Last updated, Version 10)

Data class

Protein

Predictors

HAMAP; MF_01247; [distribution of match scores in UniProtKB];[seed alignment for MF_01247]

Names

HTH-type_MalT

Identifier

MALT

Protein name

RecName: Full=HTH-type transcriptional regulator malT; AltName: Full=ATP-dependent transcriptional activator malT;

Gene name

malT

FUNCTION: Positively regulates the transcription of the maltose regulon whose gene products are responsible for uptake and catabolism of malto-oligosaccharides. Binds and recognizes a DNA motif (called the malT box): 5'-GGA[TG]GA-3' (By similarity).

SUBUNIT: Monomer in solution but oligomerizes to an active state in the presence of the positive effectors ATP and maltotriose. Interacts with malY, malK and aes, all of which negatively regulate malT activity by antagonizing maltotriose binding (By similarity).

SUBUNIT: Monomer in solution but oligomerizes to an active state in the presence of the positive effectors ATP and maltotriose (By similarity).

SIMILARITY: Contains 1 HTH luxR-type DNA-binding domain.

Pfam	PF00196; GerE; 1;
PRINTS	PR00038; HTHLUXR; 1;
PROSITE	PS00622; HTH_LUXR_1; 1; PS50043; HTH_LUXR_2; 1; trigger=PRU00411;

DNA-binding, Transcription, Transcription regulation, Activator, ATP-binding, Nucleotide-binding, Carbohydrate metabolism.

GO:0005524; Molecular function: ATP binding.
GO:0003700; Molecular function: sequence-specific DNA binding transcription factor activity.
GO:0045913; Biological process: positive regulation of carbohydrate metabolic process.
GO:0045893; Biological process: positive regulation of transcription, DNA-dependent.

From: MALT_ECOLI (P06993)
Key		From		To		Description		Condition		FTGroup
NP_BIND		39		46		ATP (Potential)		x-P-A-G-Y-G-K-T

Size range:	901-904 amino acids
Related UniRules:	None
Template:	P06993 (MALT_ECOLI)
Scope:	Bacteria; Enterobacteriales Bacteria; Vibrionales
Fusion:	Nter: None; Cter: None
Duplicate:	None
Plasmid encoded:	None