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| HAMAP annotation rule MF_01255 |
| Accession | MF_01255 |
| Dates | 13-JAN-2005 (Created) 5-JAN-2012 (Last updated, Version 16) |
| Name | Ectoine_synth |
| Scope | Bacteria |
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| FUNCTION | Catalyzes the circularization of gamma-N-acetyl-alpha,gamma-diaminobutyric acid (ADABA) to ectoine (1,4,5,6-tetrahydro-2-methyl-4-pyrimidine carboxylic acid), which is an excellent osmoprotectant (By similarity). |
| CATALYTIC ACTIVITY | N(4)-acetyl-L-2,4-diaminobutanoate = L-ectoine + H(2)O. |
| PATHWAY | Amine and polyamine biosynthesis; ectoine biosynthesis; L-ectoine from L-aspartate 4-semialdehyde; step 3/3. |
| SIMILARITY | Belongs to the ectoine synthase family. |
| Pfam | PF06339; Ectoine_synth; 1; |
| Size range: | 128-138 amino acids |
| Related Rules: | None |
| Templates: | O52251 (ECTC_HALED); O06061 (ECTC_MARHA); Q9AP33 (ECTC_BACPA): [Recover all] |
| Fusion: | None |
| Comments: | This protein is mainly found in halophilic bacteria, which synthesize ectoine as a good osmoprotectant. |