HAMAP rule MF_01257
General rule information
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| Accession | MF_01257 |
| Dates | 21-APR-2005 (Created)
1-JUN-2023 (Last updated, Version 20) |
| Name | CofD |
| Scope(s) |
Bacteria Mycobacterium Nocardia Streptomyces Archaea Archaeoglobi Halobacteria Methanobacteria Methanococci Methanomicrobia Methanopyri |
| Template(s) | P9WP81 (FBIA_MYCTU); Q8PVT6 (COFD_METMA); Q58653 (COFD_METJA); [ Recover all ] |
| Triggered by |
HAMAP; MF_01257 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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| case <OC:Actinomycetota> | |
| Identifier | FBIA |
| Protein name | RecName: Full=Phosphoenolpyruvate transferase; EC=2.7.8.28; AltName: Full=EPPG:FO PEP transferase; |
| Gene name | Name=fbiA; |
| else case <OC:Archaea> | |
| Identifier | COFD |
| Protein name | RecName: Full=2-phospho-L-lactate transferase; EC=2.7.8.28; AltName: Full=EPPG:FO PEP transferase; |
| Gene name | Name=cofD; |
| end case | |
Comments
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| case <OC:Actinomycetota> | |
| FUNCTION | Catalyzes the transfer of the phosphoenolpyruvate moiety from enoylpyruvoyl-2-diphospho-5'-guanosine (EPPG) to 7,8-didemethyl-8- hydroxy-5-deazariboflavin (FO) with the formation of dehydro coenzyme F420-0 and GMP. |
| CATALYTIC ACTIVITY | Reaction=7,8-didemethyl-8-hydroxy-5-deazariboflavin + enolpyruvoyl-2- diphospho-5'-guanosine = dehydro coenzyme F420-0 + GMP + H(+); Xref=Rhea:RHEA:27510, ChEBI:CHEBI:15378, ChEBI:CHEBI:58115, ChEBI:CHEBI:59904, ChEBI:CHEBI:143701, ChEBI:CHEBI:143705; EC=2.7.8.28; |
| else case <OC:Archaea> | |
| FUNCTION | Catalyzes the transfer of the 2-phospholactate moiety from (2S)-lactyl-2-diphospho-5'-guanosine to 7,8-didemethyl-8-hydroxy-5- deazariboflavin (FO) with the formation of oxidized coenzyme F420-0 and GMP. |
| CATALYTIC ACTIVITY | Reaction=(2S)-lactyl-2-diphospho-5'-guanosine + 7,8-didemethyl-8- hydroxy-5-deazariboflavin = GMP + H(+) + oxidized coenzyme F420-0; Xref=Rhea:RHEA:63444, ChEBI:CHEBI:15378, ChEBI:CHEBI:58115, ChEBI:CHEBI:59435, ChEBI:CHEBI:59904, ChEBI:CHEBI:59907; EC=2.7.8.28; |
| end case | |
| COFACTOR | Name=Mg(2+); Xref=ChEBI:CHEBI:18420; |
| PATHWAY | Cofactor biosynthesis; coenzyme F420 biosynthesis. |
| SUBUNIT | Homodimer. |
| SIMILARITY | Belongs to the CofD family. |
Keywords
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Gene Ontology
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| GO:0016773; Molecular function:phosphotransferase activity, alcohol group as acceptor |
| GO:0052645; Biological process:F420-0 metabolic process |
Cross-references
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Features
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| From: COFD_METMA (Q8PVT6) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| BINDING | 48 | 48 | /ligand="7,8-didemethyl-8-hydroxy-5-deazariboflavin" /ligand_id="ChEBI:CHEBI:59904" |
D | ||||||||
| BINDING | 87 | 87 | /ligand="7,8-didemethyl-8-hydroxy-5-deazariboflavin" /ligand_id="ChEBI:CHEBI:59904" |
[KR] | ||||||||
Additional information
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| Size range | 296-337 amino acids |
| Related rules |
None |
| Fusion | Nter: None Cter: None |
| Comments | CofD homologs are found in the genomes of all organisms currently known to produce coenzyme F420. These include not only the methanogenic archaea but also nonmethanogenic archaea such as Halobacteria and Archaeoglobus, as well as some eubacteria such as Streptomyces, Mycobacterium, Nocardia, and Thermobifida. The reaction was shown to be different according to the species, but IUBMB has created a single EC number (they consider it is the same enzyme). |