HAMAP

Accession	MF_01257
Dates	21-APR-2005 (Created) 27-JAN-2011 (Last updated, Version 9)

Data class

Protein

Predictors

HAMAP; MF_01257; [distribution of match scores in UniProtKB];[seed alignment for MF_01257]

Names

CofD

Identifier

COFD

Protein name

RecName: Full=2-phospho-L-lactate transferase; EC=2.7.8.28; AltName: Full=LPPG:FO 2-phospho-L-lactate transferase;

Gene name

cofD

FUNCTION: Catalyzes the transfer of the 2-phospholactate moiety from lactyl (2) diphospho-(5')guanosine (LPPG) to 7,8-didemethyl-8-hydroxy-5-deazariboflavin (FO) with the formation of the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) and GMP (By similarity).

CATALYTIC ACTIVITY: (2S)-lactyl-2-diphospho-5'-guanosine + 7,8-didemethyl-8-hydroxy-5-deazariboflavin = guanosine 5'-phosphate + coenzyme F420-0.

COFACTOR: Magnesium (By similarity).

PATHWAY: Cofactor biosynthesis; coenzyme F420 biosynthesis.

SUBUNIT: Homodimer (By similarity).

SIMILARITY: Belongs to the CofD family.

Pfam	PF01933; UPF0052; 1;
TIGRFAMs	TIGR01819; F420_cofD; 1;

Magnesium, Transferase.

GO:0016773; Molecular function: phosphotransferase activity, alcohol group as acceptor.
GO:0009108; Biological process: coenzyme biosynthetic process.

Size range:	296-337 amino acids
Related UniRules:	None
Template:	Q58653 (COFD_METJA)
Scope:	Bacteria; Mycobacterium Bacteria; Nocardia Bacteria; Streptomyces Archaea; Archaeoglobi Archaea; Halobacteria Archaea; Methanobacteria Archaea; Methanococci Archaea; Methanomicrobia Archaea; Methanopyri
Fusion:	Nter: None; Cter: None
Duplicate:	None
Plasmid encoded:	None
Comments:	CofD homologs are found in the genomes of all organisms currently known to produce coenzyme F420. These include not only the methanogenic archaea but also nonmethanogenic archaea such as Halobacteria and Archaeoglobus, as well as some eubacteria such as Streptomyces, Mycobacterium, Nocardia, and Thermobifida.