HAMAP rule MF_01265
General rule information
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Accession | MF_01265 |
Dates | 29-JUL-2005 (Created)
1-JUN-2023 (Last updated, Version 23) |
Name | NadX |
Scope(s) |
Bacteria Archaea |
Template(s) | Q9X1X6 (ASPD_THEMA); O28440 (ASPD_ARCFU); [ Recover all ] |
Triggered by |
HAMAP; MF_01265 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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Identifier | ASPD |
Protein name | RecName: Full=L-aspartate dehydrogenase; EC=1.4.1.21; |
Gene name | Name=nadX; |
Comments
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FUNCTION | Specifically catalyzes the NAD or NADP-dependent dehydrogenation of L-aspartate to iminoaspartate. |
CATALYTIC ACTIVITY | Reaction=H2O + L-aspartate + NADP(+) = H(+) + NADPH + NH4(+) + oxaloacetate; Xref=Rhea:RHEA:11784, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:16452, ChEBI:CHEBI:28938, ChEBI:CHEBI:29991, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349; EC=1.4.1.21; |
CATALYTIC ACTIVITY | Reaction=H2O + L-aspartate + NAD(+) = H(+) + NADH + NH4(+) + oxaloacetate; Xref=Rhea:RHEA:11788, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:16452, ChEBI:CHEBI:28938, ChEBI:CHEBI:29991, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=1.4.1.21; |
PATHWAY | Cofactor biosynthesis; NAD(+) biosynthesis; iminoaspartate from L-aspartate (dehydrogenase route): step 1/1. |
MISCELLANEOUS | The iminoaspartate product is unstable in aqueous solution and can decompose to oxaloacetate and ammonia. |
SIMILARITY | Belongs to the L-aspartate dehydrogenase family. |
Keywords
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Gene Ontology
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GO:0016639; Molecular function:oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor |
GO:0050661; Molecular function:NADP binding |
GO:0051287; Molecular function:NAD binding |
GO:0009435; Biological process:NAD biosynthetic process |
Cross-references
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Pfam | PF01958; DUF108; 1; |
Pfam | PF03447; NAD_binding_3; 1; |
NCBIfam | TIGR03855; NAD_NadX; 1; |
PIRSF | PIRSF005227; Asp_dh_NAD_syn; 1; |
Features
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From: ASPD_THEMA (Q9X1X6) | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
ACT_SITE | 193 | 193 | H | |||||||||
BINDING | 109 | 109 | /ligand="NAD(+)" /ligand_id="ChEBI:CHEBI:57540" |
A | ||||||||
BINDING | 164 | 164 | /ligand="NAD(+)" /ligand_id="ChEBI:CHEBI:57540" |
N |
Additional information
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Size range | 236-280 amino acids |
Related rules |
None |
Fusion | Nter: None Cter: None |