HAMAP

Accession	MF_01265
Dates	29-JUL-2005 (Created) 7-MAR-2011 (Last updated, Version 14)

Data class

Protein

Predictors

HAMAP; MF_01265; [distribution of match scores in UniProtKB];[seed alignment for MF_01265]

Names

NadX

Identifier

ASPD

Protein name

RecName: Full=Probable L-aspartate dehydrogenase; EC=1.4.1.21;

Gene name

nadX

FUNCTION: Specifically catalyzes the NAD or NADP-dependent dehydrogenation of L-aspartate to iminoaspartate (By similarity).

CATALYTIC ACTIVITY: L-aspartate + H(2)O + NAD(P)(+) = oxaloacetate + NH(3) + NAD(P)H.

PATHWAY: Cofactor biosynthesis; NAD(+) biosynthesis; iminoaspartate from L-aspartate (dehydrogenase route): step 1/1.

MISCELLANEOUS: The iminoaspartate product is unstable in aqueous solution and can decompose to oxaloacetate and ammonia (By similarity).

SIMILARITY: Belongs to the L-aspartate dehydrogenase family.

Pfam	PF01958; DUF108; 1; PF03447; NAD_binding_3; 1;

NAD, NADP, Oxidoreductase, Pyridine nucleotide biosynthesis.

GO:0016639; Molecular function: oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor.
GO:0050661; Molecular function: NADP binding.
GO:0051287; Molecular function: NAD binding.
GO:0009435; Biological process: NAD biosynthetic process.

From: ASPD_THEMA (Q9X1X6)
Key		From		To		Description		Condition		FTGroup
ACT_SITE		193		193		By similarity		H
BINDING		109		109		NAD; via amide nitrogen (By similarity)		A
BINDING		164		164		NAD (By similarity)		N

Size range:	236-280 amino acids
Related UniRules:	None
Template:	Q9X1X6 (ASPD_THEMA)
Scope:	Bacteria; Proteobacteria Bacteria; Thermotogae Archaea
Fusion:	Nter: None; Cter: None
Duplicate:	in BORBR, BORPA, BORPE
Plasmid encoded:	in RALSO