HAMAP

Accession	MF_01267
Dates	2-MAY-2006 (Created) 25-NOV-2009 (Last updated, Version 11)

Data class

Protein

Predictors

HAMAP; MF_01267; [distribution of match scores in UniProtKB];[seed alignment for MF_01267]

Names

UlaD

Identifier

ULAD

Protein name

RecName: Full=3-keto-L-gulonate-6-phosphate decarboxylase ulaD; EC=4.1.1.85; AltName: Full=3-dehydro-L-gulonate-6-phosphate decarboxylase; AltName: Full=KGPDC; AltName: Full=L-ascorbate utilization protein D;

Gene name

ulaD

FUNCTION: Catalyzes the decarboxylation of 3-keto-L-gulonate-6-P into L-xylulose-5-P. Is involved in the anaerobic L-ascorbate utilization (By similarity).

CATALYTIC ACTIVITY: 3-dehydro-L-gulonate 6-phosphate = L-xylulose 5-phosphate + CO(2).

COFACTOR: Binds 1 magnesium ion per subunit (By similarity).

PATHWAY: Cofactor degradation; L-ascorbate degradation; D-xylulose 5-phosphate from L-ascorbate: step 2/4.

SUBUNIT: Homodimer (By similarity).

INDUCTION: Induced by L-ascorbate. Repressed by ulaR (By similarity).

SIMILARITY: Belongs to the HPS/KGPDC family. KGPDC subfamily.

Pfam	PF00215; OMPdecase; 1;

Carbohydrate metabolism, Decarboxylase, Lyase.

Magnesium, Metal-binding.

GO:0000287; Molecular function: magnesium ion binding.

GO:0016831; Molecular function: carboxy-lyase activity.
GO:0019854; Biological process: L-ascorbic acid catabolic process.

From: ULAD_ECOLI (P39304)
Key		From		To		Description		Condition		FTGroup
METAL		33		33		Magnesium (By similarity)		E		1
METAL		62		62		Magnesium (By similarity)		D		1
BINDING		11		11		Substrate (By similarity)		D
BINDING		192		192		Substrate (By similarity)		R
SITE		64		64		Transition state stabilizer (By similarity)
SITE		67		67		Transition state stabilizer (By similarity)

Size range:	216-216 amino acids
Related UniRules:	None
Template:	P39304 (ULAD_ECOLI)
Scope:	Bacteria; Enterobacteriales
Fusion:	Nter: None; Cter: None
Duplicate:	None
Plasmid encoded:	None