HAMAP rule MF_01271
General rule information
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Accession | MF_01271 |
Dates | 8-NOV-2006 (Created)
19-NOV-2022 (Last updated, Version 15) |
Name | GlcNAc_kinase |
Scope(s) |
Bacteria Gammaproteobacteria |
Template(s) | P75959 (NAGK_ECOLI); Q8ZPZ9 (NAGK_SALTY); [ Recover all ] |
Triggered by |
HAMAP; MF_01271 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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Identifier | NAGK |
Protein name | RecName: Full=N-acetyl-D-glucosamine kinase; EC=2.7.1.59; AltName: Full=GlcNAc kinase; |
Gene name | Name=nagK; |
Comments
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FUNCTION | Catalyzes the phosphorylation of N-acetyl-D-glucosamine (GlcNAc) derived from cell-wall degradation, yielding GlcNAc-6-P. |
CATALYTIC ACTIVITY | Reaction=ATP + N-acetyl-D-glucosamine = ADP + H(+) + N-acetyl-D- glucosamine 6-phosphate; Xref=Rhea:RHEA:17417, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:57513, ChEBI:CHEBI:456216, ChEBI:CHEBI:506227; EC=2.7.1.59; |
PATHWAY | Cell wall biogenesis; peptidoglycan recycling. |
SIMILARITY | Belongs to the ROK (NagC/XylR) family. NagK subfamily. |
Keywords
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ATP-binding | |
Carbohydrate metabolism | |
Kinase | |
Nucleotide-binding | |
Transferase | |
case <FTGroup:1> | |
Metal-binding | |
Zinc | |
end case |
Gene Ontology
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GO:0005524; Molecular function:ATP binding | |
case <FTGroup:1> | |
GO:0008270; Molecular function:zinc ion binding | |
end case | |
GO:0045127; Molecular function:N-acetylglucosamine kinase activity | |
GO:0006044; Biological process:N-acetylglucosamine metabolic process | |
GO:0009254; Biological process:peptidoglycan turnover |
Cross-references
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Features
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From: NAGK_ECOLI (P75959) | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
BINDING | 4 | 11 | /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616" |
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BINDING | 133 | 140 | /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616" |
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BINDING | 157 | 157 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" |
H | 1 | |||||||
BINDING | 177 | 177 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" |
C | 1 | |||||||
BINDING | 179 | 179 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" |
C | 1 | |||||||
BINDING | 184 | 184 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" |
C | 1 |
Additional information
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Size range | 256-305 amino acids |
Related rules |
None |
Fusion | Nter: None Cter: None |
Comments | NagK sequences from YERPE, YERPA and YERPN (but not YERPS) are shorter, due to a probable natural frameshift in the C-terminus; they are not included in alignment. |