HAMAP rule MF_01273
General rule information
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Accession | MF_01273 |
Dates | 8-NOV-2006 (Created)
1-JUN-2023 (Last updated, Version 18) |
Name | Pantothen_kinase_2 |
Scope(s) |
Bacteria Bacillota |
Template(s) | Q2FWC7 (COAW_STAA8); Q6G7I0 (COAW_STAAS); [ Recover all ] |
Triggered by |
HAMAP; MF_01273 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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Identifier | COAW |
Protein name | RecName: Full=Type II pantothenate kinase; EC=2.7.1.33; AltName: Full=PanK-II; AltName: Full=Pantothenic acid kinase; |
Gene name | Name=coaW; |
Comments
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FUNCTION | Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis. |
CATALYTIC ACTIVITY | Reaction=(R)-pantothenate + ATP = (R)-4'-phosphopantothenate + ADP + H(+); Xref=Rhea:RHEA:16373, ChEBI:CHEBI:10986, ChEBI:CHEBI:15378, ChEBI:CHEBI:29032, ChEBI:CHEBI:30616, ChEBI:CHEBI:456216; EC=2.7.1.33; |
PATHWAY | Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)- pantothenate: step 1/5. |
SUBUNIT | Homodimer. |
SUBCELLULAR LOCATION | Cytoplasm. |
SIMILARITY | Belongs to the type II pantothenate kinase family. |
Keywords
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Gene Ontology
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GO:0005524; Molecular function:ATP binding |
GO:0004594; Molecular function:pantothenate kinase activity |
GO:0015937; Biological process:coenzyme A biosynthetic process |
GO:0005737; Cellular component:cytoplasm |
Cross-references
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Features
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From: COAW_STAAS (Q6G7I0) | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
BINDING | 6 | 13 | /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616" |
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BINDING | 121 | 125 | /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616" |
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ACT_SITE | 70 | 70 | /note="Proton acceptor" | E | ||||||||
BINDING | 99 | 99 | /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616" |
T | ||||||||
BINDING | 137 | 137 | /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616" |
[YF] | ||||||||
BINDING | 225 | 225 | /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616" |
S |
Additional information
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Size range | 262-276 amino acids |
Related rules |
None |
Fusion | Nter: None Cter: None |
Comments | There are three distinct types of pantothenate kinase, as differenciated by primary sequence analysis and biochemical properties: type I (MF_00215), type II (MF_01273) and type III (MF_01274). |