HAMAP annotation rule MF_01274
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Accession MF_01274
Dates 21-NOV-2006 (Created)
9-FEB-2012 (Last updated, Version 14)
Name Pantothen_kinase_3
Scope Bacteria
Triggered by



Identifier
COAX
Protein name
RecName: Full=Type III pantothenate kinase;
EC=2.7.1.33;
AltName: Full=PanK-III;
AltName: Full=Pantothenic acid kinase;
Gene name
coaX


FUNCTION Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis (By similarity).
CATALYTIC ACTIVITY ATP + (R)-pantothenate = ADP + (R)-4'-phosphopantothenate.
COFACTOR Monovalent cations (By similarity).
PATHWAY Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-pantothenate; step 1/5.
SUBUNIT Homodimer (By similarity).
SUBCELLULAR LOCATION Cytoplasm (By similarity).
SIMILARITY Belongs to the type III pantothenate kinase family.


Cytoplasm
ATP-binding
Coenzyme A biosynthesis
Kinase
case <FT:4>
Metal-binding
end case
Nucleotide-binding
Transferase


GO:0005524; Molecular function: ATP binding.
GO:0004594; Molecular function: pantothenate kinase activity.
case <FT:4>
GO:0043169; Molecular function: cation binding.
end case
GO:0015937; Biological process: coenzyme A biosynthetic process.
GO:0005737; Cellular component: cytoplasm.


Pfam PF03309; Pan_kinase; 1;
TIGRFAMs TIGR00671; Baf; 1;


From: COAX_PSEAE (Q9HWC1)
Key     From     To       Description   Tag   Condition   FTGroup
NP_BIND     6     13       ATP (By similarity)        
REGION     99     102       Substrate binding (By similarity)     G-x-D-x  
ACT_SITE     101     101       Proton acceptor (Potential)     D  
METAL (Optional)     121     121       Monovalent cation (Potential)     D  
BINDING (Optional)     92     92       Substrate (By similarity)     [YF]  
BINDING     124     124       ATP (Potential)     [TS]  
BINDING (Optional)     180     180       Substrate (By similarity)     [TS]  


Size range: 205-295 amino acids
Related Rules: None
Templates: Q9HWC1 (COAX_PSEAE); P37564 (COAX_BACSU); O25533 (COAX_HELPY); Q9WZY5 (COAX_THEMA): [Recover all]
Fusion: Nter: <birA>; Cter: None
Comments: There are three distinct types of pantothenate kinase, as differenciated by primary sequence analysis and biochemical properties: type I (MF_00215), type II (MF_01273) and type III (MF_01274).


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