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HAMAP annotation rule: MF_01274
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General rule information

Accession MF_01274
Dates 21-NOV-2006 (Created)
18-AUG-2010 (Last updated, Version 12)
Data class Protein
Predictors HAMAP; MF_01274; [distribution of match scores in UniProtKB];[seed alignment for MF_01274]
Names Pantothen_kinase_3


Propagated annotation

Identifier, protein and gene names
Identifier COAX
Protein name
RecName: Full=Type III pantothenate kinase;
EC=2.7.1.33;
AltName: Full=PanK-III;
AltName: Full=Pantothenic acid kinase;
Gene name coaX
Comments
FUNCTION: Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis (By similarity).
CATALYTIC ACTIVITY: ATP + (R)-pantothenate = ADP + (R)-4'-phosphopantothenate.
COFACTOR: Monovalent cations (By similarity).
PATHWAY: Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-pantothenate: step 1/5.
SUBUNIT: Homodimer (By similarity).
SUBCELLULAR LOCATION: Cytoplasm (By similarity).
SIMILARITY: Belongs to the type III pantothenate kinase family.
Cross-references
Pfam PF03309; Bvg_acc_factor; 1;
TIGRFAMs TIGR00671; baf; 1;
Keywords
Cytoplasm, ATP-binding, Coenzyme A biosynthesis, Kinase.

case <FT:4>
Metal-binding.
end case

Nucleotide-binding, Transferase.
Gene Ontology
GO:0005524; Molecular function: ATP binding.
GO:0004594; Molecular function: pantothenate kinase activity.

case <FT:4>
GO:0043169; Molecular function: cation binding.
end case

GO:0015937; Biological process: coenzyme A biosynthetic process.
GO:0005737; Cellular component: cytoplasm.
Features
From: COAX_PSEAE (Q9HWC1)
Key     From     To       Description   Condition   FTGroup
NP_BIND     6     13       ATP (By similarity)      
REGION     99     102       Substrate binding (By similarity)   G-x-D-x  
ACT_SITE     101     101       Proton acceptor (Potential)   D  
METAL (Optional)     121     121       Monovalent cation (Potential)   D  
BINDING (Optional)     92     92       Substrate (By similarity)   [YF]  
BINDING     124     124       ATP (Potential)   [TS]  
BINDING (Optional)     180     180       Substrate (By similarity)   [TS]  


Additional information

Size range: 205-295 amino acids
Related UniRules: None
Template: Q9HWC1 (COAX_PSEAE); P37564 (COAX_BACSU); O25533 (COAX_HELPY); Q9WZY5 (COAX_THEMA): [Recover all]
Scope: Bacteria
Fusion: Nter: <birA>; Cter: None
Duplicate: in FRAT1, FRATH, FRATO, FRATT, SYMTH
Plasmid encoded: None
Comments: There are three distinct types of pantothenate kinase, as differenciated by primary sequence analysis and biochemical properties: type I (MF_00215), type II (MF_01273) and type III (MF_01274).

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UniProtKB rule member sequences