HAMAP

Accession	MF_01276
Dates	29-NOV-2006 (Created) 18-AUG-2010 (Last updated, Version 9)

Data class

Protein

Predictors

HAMAP; MF_01276; [distribution of match scores in UniProtKB];[seed alignment for MF_01276]

Names

Putres_aminotrans_3

Identifier

PAT

Protein name

RecName: Full=Putrescine aminotransferase; EC=2.6.1.82; AltName: Full=Putrescine--2-oxoglutaric acid transaminase; Short=PAT; Short=PATase;

Gene name

patA

FUNCTION: Catalyzes the aminotransferase reaction from putrescine to 2-oxoglutarate, leading to glutamate and 4-aminobutanal, which spontaneously cyclizes to form 1-pyrroline. Is also able to transaminate cadaverine and, in lower extent, spermidine, but not ornithine (By similarity).

CATALYTIC ACTIVITY: Putrescine + 2-oxoglutarate = L-glutamate + 1-pyrroline + H(2)O.

COFACTOR: Pyridoxal phosphate (By similarity).

PATHWAY: Amine and polyamine degradation; putrescine degradation; 4-aminobutanal from putrescine (transaminase route): step 1/1.

SIMILARITY: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. Putrescine aminotransferase subfamily.

PROSITE	PS00600; AA_TRANSFER_CLASS_3; 1;
Pfam	PF00202; Aminotran_3; 1;
TIGRFAMs	TIGR01885; Orn_aminotrans; 1;

Aminotransferase, Pyridoxal phosphate, Transferase.

GO:0008483; Molecular function: transaminase activity.
GO:0030170; Molecular function: pyridoxal phosphate binding.
GO:0009447; Biological process: putrescine catabolic process.

From: PAT_ECOLI (P42588)
Key		From		To		Description		Condition		FTGroup
MOD_RES		300		300		N6-(pyridoxal phosphate)lysine (By similarity)		K

Size range:	459-468 amino acids
Related UniRules:	None
Template:	P42588 (PAT_ECOLI)
Scope:	Bacteria; Enterobacteriaceae
Fusion:	Nter: None; Cter: None
Duplicate:	None
Plasmid encoded:	None