HAMAP

Accession	MF_01277
Dates	9-FEB-2007 (Created) 25-NOV-2011 (Last updated, Version 10)

Data class

Protein

Predictors

HAMAP; MF_01277; [distribution of match scores in UniProtKB];[seed alignment for MF_01277]

Names

HTH-type_PurR

Identifier

PURR

Protein name

RecName: Full=HTH-type transcriptional repressor PurR; AltName: Full=Pur regulon repressor; AltName: Full=Purine nucleotide synthesis repressor;

Gene name

purR

FUNCTION: Is the main repressor of the genes involved in the de novo synthesis of purine nucleotides, regulating purB, purC, purEK, purF, purHD, purL, purMN and guaBA expression. PurR is allosterically activated to bind its cognate DNA by binding the purine corepressors, hypoxanthine or guanine, thereby effecting transcription repression (By similarity).

PATHWAY: Purine metabolism; purine nucleotide biosynthesis [regulation].

SUBUNIT: Homodimer (By similarity).

DOMAIN: Consists of two structural and functional domains: an N-terminal DNA-binding domain, approximately the first 60 residues, and a larger C-terminal domain, approximately 280 residues, which imparts the function of corepressor binding and oligomerization (By similarity).

SIMILARITY: Contains 1 HTH lacI-type DNA-binding domain.

PROSITE	PS00356; HTH_LACI_1; 1; PS50932; HTH_LACI_2; 1; trigger=PRU00111;
Pfam	PF00356; LacI; 1; PF00532; Peripla_BP_1; 1;
PRINTS	PR00036; HTHLACI; 1;

DNA-binding, Purine biosynthesis, Repressor, Transcription, Transcription regulation.

GO:0045892; Biological process: negative regulation of transcription, DNA-dependent.

From: PURR_ECOLI (P0ACP7)
Key		From		To		Description		Condition		FTGroup
DNA_BIND		4		23		H-T-H motif (By similarity)
DNA_BIND		48		56		By similarity
BINDING		73		73		Corepressor (By similarity)		[YF]
BINDING		190		190		Corepressor (By similarity)		[RK]
BINDING (Optional)		192		192		Corepressor (By similarity)		T
BINDING		221		221		Corepressor (By similarity)		F
BINDING		275		275		Corepressor (By similarity)		D

Size range:	333-341 amino acids
Related UniRules:	None
Template:	P0ACP7 (PURR_ECOLI)
Scope:	Bacteria; Gammaproteobacteria
Fusion:	Nter: None; Cter: None
Duplicate:	None
Plasmid encoded:	None