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HAMAP rule MF_01277

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General rule information [?]

Accession MF_01277
Dates 9-FEB-2007 (Created)
19-NOV-2022 (Last updated, Version 19)
Name HTH_type_PurR
Scope(s) Bacteria
Gammaproteobacteria
Template(s) P0ACP7 (PURR_ECOLI); [ Recover all ]
Triggered by HAMAP; MF_01277 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier PURR
Protein name RecName: Full=HTH-type transcriptional repressor PurR;
AltName: Full=Pur regulon repressor;
AltName: Full=Purine nucleotide synthesis repressor;
Gene name Name=purR;

Comments [?]

FUNCTIONIs the main repressor of the genes involved in the de novo synthesis of purine nucleotides, regulating purB, purC, purEK, purF, purHD, purL, purMN and guaBA expression. PurR is allosterically activated to bind its cognate DNA by binding the purine corepressors, hypoxanthine or guanine, thereby effecting transcription repression.
PATHWAYPurine metabolism; purine nucleotide biosynthesis [regulation].
SUBUNITHomodimer.
DOMAINConsists of two structural and functional domains: an N- terminal DNA-binding domain, approximately the first 60 residues, and a larger C-terminal domain, approximately 280 residues, which imparts the function of corepressor binding and oligomerization.

Keywords [?]


Gene Ontology [?]

GO:0045892; Biological process:negative regulation of DNA-templated transcription

Cross-references [?]

PROSITE PS00356; HTH_LACI_1; 1;
PROSITE PS50932; HTH_LACI_2; 1;
Pfam PF00356; LacI; 1;
Pfam PF00532; Peripla_BP_1; 1;
PRINTS PR00036; HTHLACI; 1;

Features [?]

From: PURR_ECOLI (P0ACP7)
Key From To Description Tag Condition FTGroup
DNA_BIND 4 23 /note="H-T-H motif"
DNA_BIND 48 56
BINDING 73 73 /ligand="hypoxanthine"
/ligand_id="ChEBI:CHEBI:17368"
[YF]
BINDING 190 190 /ligand="hypoxanthine"
/ligand_id="ChEBI:CHEBI:17368"
[RK]
BINDING 192 192 /ligand="hypoxanthine"
/ligand_id="ChEBI:CHEBI:17368"
T
BINDING 221 221 /ligand="hypoxanthine"
/ligand_id="ChEBI:CHEBI:17368"
F
BINDING 275 275 /ligand="hypoxanthine"
/ligand_id="ChEBI:CHEBI:17368"
D

Additional information [?]

Size range 333-341 amino acids
Related rules None
Fusion Nter: None Cter: None



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