Annotation rule MF_01277
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General rule information [?]

Accession MF_01277
Dates 9-FEB-2007 (Created)
17-DEC-2013 (Last updated, Version 12)
Name HTH_type_PurR
Scope Bacteria; Gammaproteobacteria

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
PURR
Protein name
RecName: Full=HTH-type transcriptional repressor PurR;
AltName: Full=Pur regulon repressor;
AltName: Full=Purine nucleotide synthesis repressor;
Gene name
purR

Comments [?]

Function Is the main repressor of the genes involved in the de novo synthesis of purine nucleotides, regulating purB, purC, purEK, purF, purHD, purL, purMN and guaBA expression. PurR is allosterically activated to bind its cognate DNA by binding the purine corepressors, hypoxanthine or guanine, thereby effecting transcription repression (By similarity).
Pathway Purine metabolism; purine nucleotide biosynthesis [regulation].
Subunit Homodimer (By similarity).
Domain Consists of two structural and functional domains: an N-terminal DNA-binding domain, approximately the first 60 residues, and a larger C-terminal domain, approximately 280 residues, which imparts the function of corepressor binding and oligomerization (By similarity).
Similarity Contains 1 HTH lacI-type DNA-binding domain.

Keywords [?]


Gene Ontology [?]

GO:0045892; Biological process: negative regulation of transcription, DNA-templated.

Cross-references [?]

PROSITE PS00356; HTH_LACI_1; 1;
PS50932; HTH_LACI_2; 1; trigger=PRU00111;
Pfam PF00356; LacI; 1;
PF00532; Peripla_BP_1; 1;
PRINTS PR00036; HTHLACI; 1;

Features [?]

From: PURR_ECOLI (P0ACP7)
Key     From     To       Description   Tag   Condition   FTGroup
DNA_BIND     4     23       H-T-H motif (By similarity)        
DNA_BIND     48     56       By similarity        
BINDING     73     73       Corepressor (By similarity)     [YF]  
BINDING     190     190       Corepressor (By similarity)     [RK]  
BINDING (Optional)     192     192       Corepressor (By similarity)     T  
BINDING     221     221       Corepressor (By similarity)     F  
BINDING     275     275       Corepressor (By similarity)     D  

Additional information [?]

Size range 333-341 amino acids
Related rules None
Template P0ACP7 (PURR_ECOLI)
Fusion None