HAMAP

Accession	MF_01280
Dates	1-OCT-2007 (Created) 18-AUG-2010 (Last updated, Version 8)

Data class

Protein

Predictors

HAMAP; MF_01280; [distribution of match scores in UniProtKB];[seed alignment for MF_01280]

Names

Diacylglyc_glucosyltr

Identifier

UGTP

Protein name

RecName: Full=Processive diacylglycerol glucosyltransferase; EC=2.4.1.-; AltName: Full=Beta-gentiobiosyldiacylglycerol synthase; AltName: Full=DGlcDAG synthase; AltName: Full=Diglucosyldiacylglycerol synthase; AltName: Full=Glc2-DAG synthase; AltName: Full=Monoglucosyldiacylglycerol synthase; Short=MGlcDAG synthase; AltName: Full=Triglucosyldiacylglycerol synthase; Short=TGlcDAG synthase; AltName: Full=UDP glucosyltransferase; AltName: Full=UDP-glucose:1,2-diacylglycerol-3-beta-D-glucosyltransferase;

Gene name

ugtP

FUNCTION: Is a processive glucosyltransferase involved in the synthesis of both bilayer- and non-bilayer-forming membrane glycolipids. Is able to successively transfer up to three glucosyl residues to diacylglycerol (DAG), thereby catalyzing the formation of mono-, di- and triglucosyldiacylglycerol. Diglucosyldiacylglycerol (Glc2-DAG) is the predominant glycolipid found in Bacillales and is also used as a membrane anchor for lipoteichoic acid (LTA) (By similarity).

CATALYTIC ACTIVITY: UDP-glucose + 1,2-diacylglycerol = UDP + 1,2-diacyl-3-(O-beta-D-glucopyranosyl)-sn-glycerol.

CATALYTIC ACTIVITY: UDP-glucose + 1,2-diacyl-3-(O-beta-D-glucopyranosyl)-sn-glycerol = UDP + 1,2-diacyl-3-(O-beta-D-glucopyranosyl(1->6)-O-beta-D-glucopyranosyl)-sn-glycerol.

CATALYTIC ACTIVITY: UDP-glucose + 1,2-diacyl-3-(O-beta-D-glucopyranosyl(1->6)-O-beta-D-glucopyranosyl)-sn-glycerol = UDP + 1,2-diacyl-3-(O-beta-D-glucopyranosyl(1->6)-O-beta-D-glucopyranosyl(1->6)-O-beta-D-glucopyranosyl)-sn-glycerol.

PATHWAY: Glycolipid metabolism; diglucosyl-diacylglycerol biosynthesis.

SIMILARITY: Belongs to the glycosyltransferase 28 family. UgtP subfamily.

Pfam	PF00534; Glycos_transf_1; 1; PF06925; MGDG_synth; 1; PF04101; Glyco_tran_28_C; 1;

Carbohydrate metabolism, Glycosyltransferase, Transferase.

GO:0035251; Molecular function: UDP-glucosyltransferase activity.
GO:0009247; Biological process: glycolipid biosynthetic process.

Size range:	382-391 amino acids
Related UniRules:	None
Template:	P54166 (UGTP_BACSU); Q5HH69 (UGTP_STAAC); Q2FZP7 (UGTP_STAA8): [Recover all]
Scope:	Bacteria; Bacillales
Fusion:	Nter: None; Cter: None
Duplicate:	None
Plasmid encoded:	None