HAMAP

Accession	MF_01286
Dates	19-AUG-2008 (Created) 27-JUN-2011 (Last updated, Version 5)

Data class

Protein

Predictors

HAMAP; MF_01286; [distribution of match scores in UniProtKB];[seed alignment for MF_01286]

Names

DGGGP_synth

Identifier

DGGGP

Protein name

RecName: Full=Digeranylgeranylglyceryl phosphate synthase; Short=DGGGP synthase; Short=DGGGPS; EC=2.5.1.42; AltName: Full=(S)-2,3-di-O-geranylgeranylglyceryl phosphate synthase; AltName: Full=Geranylgeranylglycerol-phosphate geranylgeranyltransferase;

FUNCTION: Prenyltransferase that catalyzes the transfer of the geranylgeranyl moiety of geranylgeranyl diphosphate (GGPP) to the C2 hydroxyl of (S)-3-O-geranylgeranylglyceryl phosphate (GGGP). This reaction is the second ether-bond-formation step in the biosynthesis of archaeal membrane lipids (By similarity).

CATALYTIC ACTIVITY: Geranylgeranyl diphosphate + sn-3-O-(geranylgeranyl)glycerol 1-phosphate = diphosphate + 2,3-bis-O-(geranylgeranyl)glycerol 1-phosphate.

COFACTOR: Magnesium (By similarity).

PATHWAY: Membrane lipid metabolism; glycerophospholipid metabolism.

SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein (By similarity).

SIMILARITY: Belongs to the UbiA prenyltransferase family. DGGGP synthase subfamily.

Pfam	PF01040; UbiA; 1;
General	Transmembrane; -; 5-9; trigger=Yes;

Cell membrane, Magnesium, Membrane, Phospholipid biosynthesis, Transferase, Transmembrane, Transmembrane helix.

GO:0000287; Molecular function: magnesium ion binding.
GO:0047295; Molecular function: geranylgeranylglycerol-phosphate geranylgeranyltransferase activity.
GO:0008654; Biological process: phospholipid biosynthetic process.
GO:0005886; Cellular component: plasma membrane.

Size range:	267-303 amino acids
Related UniRules:	None
Template:	Q9UWY6 (DGGGP_SULSO); O27170 (DGGGP_METTH): [Recover all]
Scope:	Archaea
Fusion:	Nter: None; Cter: None
Duplicate:	None
Plasmid encoded:	None