HAMAP

Accession	MF_01287
Dates	20-AUG-2008 (Created) 15-MAR-2011 (Last updated, Version 9)

Data class

Protein

Predictors

HAMAP; MF_01287; [distribution of match scores in UniProtKB];[seed alignment for MF_01287]

Names

DGGGPL_reductase

Identifier

GGR

Protein name

RecName: Full=Digeranylgeranylglycerophospholipid reductase; Short=DGGGPL reductase; EC=1.3.1.-; AltName: Full=2,3-di-O-geranylgeranylglyceryl phosphate reductase; AltName: Full=Geranylgeranyl reductase; Short=GGR;

FUNCTION: Is involved in the reduction of 2,3-digeranylgeranylglycerophospholipids (unsaturated archaeols) into 2,3-diphytanylglycerophospholipids (saturated archaeols) in the biosynthesis of archaeal membrane lipids. Catalyzes the formation of archaetidic acid (2,3-di-O-phytanyl-sn-glyceryl phosphate) from 2,3-di-O-geranylgeranylglyceryl phosphate (DGGGP) via the hydrogenation of each double bond of the isoprenoid chains (By similarity).

CATALYTIC ACTIVITY: 2,3-bis-O-(geranylgeranyl)glycerol 1-phosphate + NAD(+) = 2,3-bis-O-(phytanyl)glycerol 1-phosphate + NADH.

COFACTOR: Binds 1 FAD per subunit (By similarity).

PATHWAY: Membrane lipid metabolism; glycerophospholipid metabolism.

MISCELLANEOUS: Reduction reaction proceeds via syn addition of hydrogen for double bonds (By similarity).

SIMILARITY: Belongs to the geranylgeranyl reductase family. DGGGPL reductase subfamily.

PRINTS	PR00368; FADPNR; 1;
TIGRFAMs	TIGR02032; GG-red-SF; 1;

FAD, Flavoprotein, NAD, Oxidoreductase, Phospholipid biosynthesis.

GO:0016628; Molecular function: oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor.
GO:0050660; Molecular function: flavin adenine dinucleotide binding.
GO:0051287; Molecular function: NAD binding.
GO:0008654; Biological process: phospholipid biosynthetic process.

From: GGR_THEAC (Q9HKS9)
Key		From		To		Description		Condition		FTGroup
NP_BIND		10		14		FAD (By similarity)		G-[AGS]-[GR]-[PVI]-[AGS]
NP_BIND		33		35		FAD (By similarity)		[ED]-[KR]-x
NP_BIND		44		47		FAD (By similarity)		C-[AG]-[EG]-[GA]
NP_BIND		295		296		FAD (By similarity)		G-[ILM]
REGION		208		214		Substrate binding (By similarity)		G-Y-[VILAF]-[WL]-x-[FI]-P
REGION		291		294		Substrate binding (By similarity)		[ILFVM]-[TSEH]-G-G
BINDING		100		100		FAD (By similarity)		R
BINDING		283		283		FAD (By similarity)		D

Size range:	375-408 amino acids
Related UniRules:	None
Template:	O29786 (GGR_ARCFU); Q9HKS9 (GGR_THEAC): [Recover all]
Scope:	Archaea
Fusion:	Nter: None; Cter: None
Duplicate:	in METBU, METKA, METST, METTH
Plasmid encoded:	None