HAMAP

Accession	MF_01294
Dates	5-NOV-2008 (Created) 18-NOV-2010 (Last updated, Version 5)

Data class

Protein

Predictors

HAMAP; MF_01294; [distribution of match scores in UniProtKB];[seed alignment for MF_01294]

Names

TagBP_aldolase_GatY

Identifier

GATY

Protein name

RecName: Full=D-tagatose-1,6-bisphosphate aldolase subunit GatY; Short=TBPA; Short=TagBP aldolase; EC=4.1.2.40; AltName: Full=D-tagatose-bisphosphate aldolase class II; AltName: Full=Tagatose-bisphosphate aldolase;

Gene name

gatY

FUNCTION: Catalytic subunit of the tagatose-1,6-bisphosphate aldolase GatYZ, which catalyzes the reversible aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to produce tagatose 1,6-bisphosphate (TBP). Requires GatZ subunit for full activity and stability. Is involved in the catabolism of galactitol (By similarity).

CATALYTIC ACTIVITY: D-tagatose 1,6-bisphosphate = glycerone phosphate + D-glyceraldehyde 3-phosphate.

COFACTOR: Binds 1 zinc ion per subunit (By similarity).

PATHWAY: Carbohydrate metabolism; D-tagatose 6-phosphate degradation; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-tagatose 6-phosphate: step 2/2.

SUBUNIT: Forms a complex with GatZ (By similarity).

SIMILARITY: Belongs to the class II fructose-bisphosphate aldolase family. TagBP aldolase GatY subfamily.

PROSITE	PS00602; ALDOLASE_CLASS_II_1; 1; PS00806; ALDOLASE_CLASS_II_2; 1;
Pfam	PF01116; F_bP_aldolase; 1;
TIGRFAMs	TIGR00167; cbbA; 1; TIGR01858; tag_bisphos_ald; 1;

Galactitol metabolism, Lyase.

Metal-binding, Zinc.

GO:0008270; Molecular function: zinc ion binding.

GO:0009025; Molecular function: tagatose-bisphosphate aldolase activity.
GO:0019404; Biological process: galactitol catabolic process.

From: GATY_ECOLI (P0C8J6)
Key		From		To		Description		Condition		FTGroup
REGION		230		233		Dihydroxyacetone phosphate binding (By similarity)		N-x-A-T
REGION		209		211		Dihydroxyacetone phosphate binding (By similarity)		G-x-S
ACT_SITE		82		82		Proton donor (By similarity)		D
METAL		83		83		Zinc; catalytic (By similarity)		H		1
METAL		180		180		Zinc; catalytic (By similarity)		H		1
METAL		208		208		Zinc; catalytic (By similarity)		H		1
BINDING		181		181		Dihydroxyacetone phosphate; via amide nitrogen (By similarity)		[GC]

Size range:	284-284 amino acids
Related UniRules:	MF_01293 (KBAY)
Template:	P0C8J6 (GATY_ECOLI); P0C8J7 (GATY_ECOLX); Q8VS16 (GATY_KLEOX): [Recover all]
Scope:	Bacteria; Enterobacteriales
Fusion:	Nter: None; Cter: None
Duplicate:	None
Plasmid encoded:	None
Comments:	Subunit gatZ is described in MF_01296. In some enterobacteria, a second D-tagatose-1,6-bisphosphate aldolase is present: kbaYZ (MF_01293 and MF_01295).