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HAMAP rule MF_01307

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General rule information [?]

PURL https://purl.expasy.org/hamap/rule/MF_01307
Accession MF_01307
Dates 28-FEB-2005 (Created)
20-JAN-2026 (Last updated, Version )
Name Ribosomal_uS5
Scope(s) Bacteria
Archaea
Plastid
Template(s) P02357; P21467; P0A7W1; P0A7W4; Q5SHQ5; Q5JJG8; [ Recover all ]
Triggered by
case c? <OC:Bacteria> or <OG:Chloroplast>
HAMAP; MF_01307_B (Get profile general information and statistics)
end case
case c? <OC:Archaea>
HAMAP; MF_01307_A (Get profile general information and statistics)
end case

Propagated annotation [?]

Identifier, protein and gene names [?]

case <OC:Bacteria> and not <OC:Cyanobacteriota>
Identifier RS5
Protein name RecName: Full=Small ribosomal subunit protein uS5;
Gene name Name=rpsE;
else case <OC:Cyanobacteriota>
Identifier RS5
Protein name RecName: Full=Small ribosomal subunit protein uS5;
Gene name Name=rpsE; Synonyms=rps5;
else case <OC:Archaea>
Identifier RS5
Protein name RecName: Full=Small ribosomal subunit protein uS5;
Gene name Name=rps5;
else case <OG:Chloroplast>
Identifier RR5
Protein name RecName: Full=Small ribosomal subunit protein uS5c;
Gene name Name=rps5;
end case

Comments [?]

case <OC:Bacteria>
FUNCTIONComponent of the small ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.
FUNCTIONWith uS4 and uS12 plays an important role in translational accuracy.
FUNCTIONLocated at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body.
SUBUNITPart of the 30S ribosomal subunit. Contacts proteins uS4 and uS8.
else case <OC:Archaea>
FUNCTIONComponent of the small ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.
FUNCTIONWith uS4 and uS12 plays an important role in translational accuracy.
case <FTGroup:1>
COFACTOR Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Note=Binds 1 zinc ion per subunit.;
end case
SUBUNITPart of the 30S ribosomal subunit. Contacts protein uS4.
else case <OG:Chloroplast>
FUNCTIONComponent of the small ribosomal subunit. This ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the plastid.
FUNCTIONWith uS4 and uS12 plays an important role in translational accuracy.
SUBUNITPart of the 30S ribosomal subunit. Contacts protein uS4.
SUBCELLULAR LOCATIONPlastid, chloroplast.
end case
DOMAINThe N-terminal domain interacts with the head of the 30S subunit; the C-terminal domain interacts with the body and contacts protein uS4. The interaction surface between uS4 and uS5 is involved in control of translational fidelity.
SIMILARITYBelongs to the universal ribosomal protein uS5 family.

Keywords [?]

Ribonucleoprotein
Ribosomal protein
RNA-binding
rRNA-binding
case <FTGroup:1>
Metal-binding
Zinc
end case

Gene Ontology [?]

GO:0019843; Molecular function:rRNA binding
GO:0006412; Biological process:translation
case <FTGroup:1>
GO:0008270; Molecular function:zinc ion binding
end case
case <OG:Chloroplast>
GO:0009507; Cellular component:chloroplast
end case

Cross-references [?]

Pfam PF00333; Ribosomal_S5; 1;
Pfam PF03719; Ribosomal_S5_C; 1;
NCBIfam TIGR01021; RpsE_bact; 1;
NCBIfam TIGR01020; RpsE_arch; 1;
PROSITE PS00585; RIBOSOMAL_S5; 1;
PROSITE PS50881; S5_DSRBD; 1;

Features [?]

From: RS5_THEKO (Q5JJG8)
Key From To Description Tag Condition FTGroup
BINDING 127 127 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"		 C 1
BINDING 132 132 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"		 C 1
BINDING 134 134 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"		 C 1
BINDING 138 138 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"		 H 1

Additional information [?]

Size range 197-238 amino acids
Related rules None
Fusion Nter: None Cter: None
Comments CARRP has been made atypical.



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