HAMAP annotation rule MF_01312
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Accession MF_01312
Dates 20-MAR-2003 (Created)
6-JAN-2012 (Last updated, Version 30)
Name NorV
Scope Bacteria; Aeromonas
Bacteria; Aliivibrio
Bacteria; Citrobacter
Bacteria; Escherichia
Bacteria; Enterobacter
Bacteria; Klebsiella
Bacteria; Pectobacterium
Bacteria; Salmonella
Bacteria; Serratia
Bacteria; Shigella
Bacteria; Vibrio
Triggered by



Identifier
NORV
Protein name
RecName: Full=Anaerobic nitric oxide reductase flavorubredoxin;
Short=FlRd;
Short=FlavoRb;
Gene name
norV, flrD


FUNCTION Anaerobic nitric oxide reductase; uses NADH to detoxify nitric oxide (NO), protecting several 4Fe-4S NO-sensitive enzymes. Has at least 2 reductase partners, only one of which (NorW, flavorubredoxin reductase) has been identified. NO probably binds to the di-iron center; electrons enter from the NorW at rubredoxin and are transferred sequentially to the FMN center and the di-iron center. Also able to function as an aerobic oxygen reductase (By similarity).
case <FTGroup:1> and <FTGroup:2>
COFACTOR Binds 3 iron ions per monomer (By similarity).
end case
case <Feature:PS50902>
COFACTOR Binds 1 FMN per monomer (By similarity).
end case
PATHWAY Nitrogen metabolism; nitric oxide reduction.
SUBUNIT Homotetramer (By similarity).
SUBCELLULAR LOCATION Cytoplasm (By similarity).
case <FT:1>
SIMILARITY In the N-terminal section; belongs to the zinc metallo-hydrolase group 3 family.
end case
case <Feature:PS50902>
SIMILARITY Contains 1 flavodoxin-like domain.
end case
case <Feature:PS50903>
SIMILARITY Contains 1 rubredoxin-like domain.
end case


Cytoplasm
Transport
Electron transport
Oxidoreductase
case <Feature:PS50902>
Flavoprotein
FMN
end case
case <FTGroup:1> or <FTGroup:2>
Metal-binding
Iron
end case


GO:0009055; Molecular function: electron carrier activity.
GO:0016491; Molecular function: oxidoreductase activity.
GO:0055114; Biological process: oxidation-reduction process.
GO:0005737; Cellular component: cytoplasm.


Pfam PF00258; Flavodoxin_1; 1;
PF00753; Lactamase_B; 1;
PF00301; Rubredoxin; 1;
PF00070; Pyr_redox; 1;
PIRSF PIRSF005243; ROO; 1;
PRINTS PR00163; RUBREDOXIN; 1;
PROSITE PS50902; FLAVODOXIN_LIKE; 1; trigger=PRU00088;
PS50903; RUBREDOXIN_LIKE; 1;


From: NORV_ECOLI (Q46877)
Key     From     To       Description   Tag   Condition   FTGroup
DOMAIN     423     474       Rubredoxin-like        
REGION     30     210       Zinc metallo-hydrolase        
METAL     79     79       Iron 1 (By similarity)     H   1
METAL     81     81       Iron 1 (By similarity)     E   1
METAL     83     83       Iron 2 (By similarity)     D   1
METAL     147     147       Iron 1 (By similarity)     H   1
METAL     166     166       Iron 1 (By similarity)     D   1
METAL     166     166       Iron 2 (By similarity)     D   1
METAL     227     227       Iron 2 (By similarity)     H   1
METAL     428     428       Iron 3 (By similarity)     C   2
METAL     431     431       Iron 3 (By similarity)     C   2
METAL     461     461       Iron 3 (By similarity)     C   2
METAL     464     464       Iron 3 (By similarity)     C   2


Size range: 479-521 amino acids
Related Rules: None
Template: Q46877 (NORV_ECOLI)
Fusion: None
Comments: ECO57 lacks the flavodoxin-like domain and is not used in alignment. Restricted to lineages where there is norR upstream and norW downstream.


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