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Annotation rule MF_01312
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General rule information [?]

Accession MF_01312
Dates 20-MAR-2003 (Created)
19-DEC-2016 (Last updated, Version 33)
Name NorV
Scope Bacteria; Aeromonas
Bacteria; Aliivibrio
Bacteria; Citrobacter
Bacteria; Escherichia
Bacteria; Enterobacter
Bacteria; Klebsiella
Bacteria; Pectobacterium
Bacteria; Salmonella
Bacteria; Serratia
Bacteria; Shigella
Bacteria; Vibrio
Template Q46877 (NORV_ECOLI)

Propagated annotation [?]

Identifier, protein and gene names [?]

Protein name
RecName: Full=Anaerobic nitric oxide reductase flavorubredoxin;
Gene name
norV, flrD

Comments [?]

Function Anaerobic nitric oxide reductase; uses NADH to detoxify nitric oxide (NO), protecting several 4Fe-4S NO-sensitive enzymes. Has at least 2 reductase partners, only one of which (NorW, flavorubredoxin reductase) has been identified. NO probably binds to the di-iron center; electrons enter from the NorW at rubredoxin and are transferred sequentially to the FMN center and the di-iron center. Also able to function as an aerobic oxygen reductase.
case <FTGroup:1> and <FTGroup:2>
Cofactor Fe cation
Note: Binds 3 Fe cations per monomer.
end case
case <Feature:PS50902>
Cofactor FMN
Note: Binds 1 FMN per monomer.
end case
Pathway Nitrogen metabolism; nitric oxide reduction.
Subunit Homotetramer.
Subcellular location Cytoplasm.
case <FT:1>
Similarity In the N-terminal section; belongs to the zinc metallo-hydrolase group 3 family.
end case

Keywords [?]

case <Feature:PS50902>
end case
case <FTGroup:1> or <FTGroup:2>
end case

Gene Ontology [?]

GO:0009055; Molecular function: electron carrier activity.
GO:0016491; Molecular function: oxidoreductase activity.
GO:0055114; Biological process: oxidation-reduction process.
GO:0005737; Cellular component: cytoplasm.

Cross-references [?]

Pfam PF00258; Flavodoxin_1; 1;
PF00753; Lactamase_B; 1;
PF00301; Rubredoxin; 1;
PF00070; Pyr_redox; 1;
PIRSF PIRSF005243; ROO; 1;
PROSITE PS50902; FLAVODOXIN_LIKE; 1; trigger=PRU00088;

Features [?]

From: NORV_ECOLI (Q46877)
Key     From     To       Description   Tag   Condition   FTGroup
DOMAIN     423     474       Rubredoxin-like        
REGION     30     210       Zinc metallo-hydrolase        
METAL     79     79       Iron 1     H   1
METAL     81     81       Iron 1     E   1
METAL     83     83       Iron 2     D   1
METAL     147     147       Iron 1     H   1
METAL     166     166       Iron 1     D   1
METAL     166     166       Iron 2     D   1
METAL     227     227       Iron 2     H   1
METAL     428     428       Iron 3     C   2
METAL     431     431       Iron 3     C   2
METAL     461     461       Iron 3     C   2
METAL     464     464       Iron 3     C   2

Additional information [?]

Size range 479-521 amino acids
Related rules None
Fusion None
Comments ECO57 lacks the flavodoxin-like domain and is not used in alignment. Restricted to lineages where there is norR upstream and norW downstream.