HAMAP rule MF_01319
General rule information
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| Accession | MF_01319 |
| Dates | 27-AUG-2003 (Created)
15-FEB-2022 (Last updated, Version 30) |
| Name | ResA |
| Scope(s) |
Bacteria Bacillaceae |
| Template(s) | P35160 (RESA_BACSU); [ Recover all ] |
| Triggered by |
HAMAP; MF_01319 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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| Identifier | RESA |
| Protein name | RecName: Full=Thiol-disulfide oxidoreductase ResA; |
| Gene name | Name=resA; |
Comments
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| FUNCTION | Thiol-disulfide oxidoreductase which is required in disulfide reduction during c-type cytochrome synthesis. May accept reducing equivalents from CcdA, leading to breakage of disulfide bonds in apocytochrome c; following this reduction heme can be covalently attached. |
| PATHWAY | Protein modification; cytochrome c assembly. |
| SUBCELLULAR LOCATION | Cell membrane; Single-pass type II membrane protein. Note=The thioredoxin-like motif is exposed on the outside of the membrane. |
| SIMILARITY | Belongs to the thioredoxin family. ResA subfamily. |
Keywords
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| Cell membrane | |
| Cytochrome c-type biogenesis | |
| case <FT:2> | |
| Disulfide bond | |
| end case | |
| Membrane | |
| Oxidoreductase | |
| Redox-active center | |
| Signal-anchor | |
| Transmembrane | |
| Transmembrane helix | |
Gene Ontology
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| GO:0015036; Molecular function:disulfide oxidoreductase activity |
| GO:0017004; Biological process:cytochrome complex assembly |
| GO:0005886; Cellular component:plasma membrane |
Cross-references
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Features
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| From: RESA_BACSU (P35160) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| TRANSMEM | 11 | 30 | /note="Helical; Signal-anchor for type II membrane protein" | |||||||||
| DISULFID | 74 | 77 | /note="Redox-active" | C-x-P-C | ||||||||
Additional information
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| Size range | 173-192 amino acids |
| Related rules |
None |
| Fusion | Nter: None Cter: None |