HAMAP rule MF_01339
General rule information
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| PURL | https://purl.expasy.org/hamap/rule/MF_01339 |
| Accession | MF_01339 |
| Dates | 8-NOV-2005 (Created)
2-SEP-2024 (Last updated, Version 21) |
| Name | RuBisCO_L_type2 |
| Scope(s) |
Bacteria Rhodopseudomonas Rhodobacterales Rhodospirillales Comamonadaceae Thiomonas Hydrogenophilales Rhodocyclaceae Halothiobacillus Hydrogenovibrio Thiomicrospira |
| Template(s) | P04718 (RBL2_RHORU); [ Recover all ] |
| Triggered by |
HAMAP; MF_01339 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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| Identifier | RBL2 |
| Protein name | RecName: Full=Ribulose bisphosphate carboxylase; Short=RuBisCO; EC=4.1.1.39; |
| Gene name | Name=cbbM; |
Comments
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| FUNCTION | RuBisCO catalyzes two reactions: the carboxylation of D- ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate. Both reactions occur simultaneously and in competition at the same active site. |
| CATALYTIC ACTIVITY | Reaction=2 (2R)-3-phosphoglycerate + 2 H(+) = D-ribulose 1,5- bisphosphate + CO2 + H2O; Xref=Rhea:RHEA:23124, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:16526, ChEBI:CHEBI:57870, ChEBI:CHEBI:58272; EC=4.1.1.39; |
| CATALYTIC ACTIVITY | Reaction=D-ribulose 1,5-bisphosphate + O2 = 2-phosphoglycolate + (2R)- 3-phosphoglycerate + 2 H(+); Xref=Rhea:RHEA:36631, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:57870, ChEBI:CHEBI:58033, ChEBI:CHEBI:58272; |
| case <FTGroup:1> | |
| COFACTOR | Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Note=Binds 1 Mg(2+) ion per subunit.; |
| end case | |
| SUBUNIT | Homodimer. |
| MISCELLANEOUS | The basic functional RuBisCO is composed of a large chain homodimer in a 'head-to-tail' conformation. In contrast to form I RuBisCO, the form II RuBisCO are composed solely of large subunits. |
| SIMILARITY | Belongs to the RuBisCO large chain family. Type II subfamily. |
Keywords
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| Calvin cycle | |
| Carbon dioxide fixation | |
| Lyase | |
| case <FTGroup:1> | |
| Magnesium | |
| Metal-binding | |
| end case | |
| Monooxygenase | |
| Oxidoreductase | |
| case <Property:PHOTOSYN> | |
| Photosynthesis | |
| end case | |
Gene Ontology
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| case <FTGroup:1> | |
| GO:0000287; Molecular function:magnesium ion binding | |
| end case | |
| GO:0016984; Molecular function:ribulose-bisphosphate carboxylase activity | |
Cross-references
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| PROSITE | PS00157; RUBISCO_LARGE; 1; |
| Pfam | PF00016; RuBisCO_large; 1; |
| Pfam | PF02788; RuBisCO_large_N; 1; |
Features
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| From: RBL2_RHORU (P04718) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| ACT_SITE | 166 | 166 | /note="Proton acceptor" | K | ||||||||
| ACT_SITE | 287 | 287 | /note="Proton acceptor" | H | ||||||||
| BINDING | 191 | 191 | /ligand="Mg(2+)" /ligand_id="ChEBI:CHEBI:18420" /note="via carbamate group" |
K | 1 | |||||||
| BINDING | 193 | 193 | /ligand="Mg(2+)" /ligand_id="ChEBI:CHEBI:18420" |
D | 1 | |||||||
| BINDING | 194 | 194 | /ligand="Mg(2+)" /ligand_id="ChEBI:CHEBI:18420" |
E | 1 | |||||||
| SITE | 329 | 329 | /note="Transition state stabilizer" | K | ||||||||
| BINDING | 111 | 111 | /ligand="substrate" /note="in homodimeric partner" |
N | ||||||||
| BINDING | 168 | 168 | /ligand="substrate" | K | ||||||||
| BINDING | 288 | 288 | /ligand="substrate" | R | ||||||||
| BINDING | 321 | 321 | /ligand="substrate" | H | ||||||||
| BINDING | 368 | 368 | /ligand="substrate" | S | ||||||||
| MOD_RES | 191 | 191 | /note="N6-carboxylysine" | K | ||||||||
Additional information
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| Size range | 458-466 amino acids |
| Related rules |
MF_01133 MF_01338 |
| Fusion | Nter: None Cter: None |