HAMAP rule MF_01346
General rule information
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| Accession | MF_01346 |
| Dates | 11-APR-2006 (Created)
1-JUN-2023 (Last updated, Version 57) |
| Name | ATP_synth_alpha_bact |
| Scope(s) |
Bacteria Plastid |
| Template(s) | P0ABB0 (ATPA_ECOLI); [ Recover all ] |
| Triggered by |
case c? <OC:Bacteria> or <OG:Chloroplast>
HAMAP; MF_01346 (Get profile general information and statistics) end case
|
Propagated annotation
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Identifier, protein and gene names
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| Identifier | ATPA |
| case <OC:Bacteria> | |
| Protein name | RecName: Full=ATP synthase subunit alpha; EC=7.1.2.2; AltName: Full=ATP synthase F1 sector subunit alpha; AltName: Full=F-ATPase subunit alpha; |
| else case <OG:Chloroplast> | |
| Protein name | RecName: Full=ATP synthase subunit alpha, chloroplastic; EC=7.1.2.2; AltName: Full=ATP synthase F1 sector subunit alpha; AltName: Full=F-ATPase subunit alpha; |
| end case | |
| Gene name | Name=atpA; |
Comments
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| FUNCTION | Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit. |
| CATALYTIC ACTIVITY | Reaction=ATP + 4 H(+)(in) + H2O = ADP + 5 H(+)(out) + phosphate; Xref=Rhea:RHEA:57720, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=7.1.2.2; |
| case <OG:Chloroplast> or <Property:PHOTOSYN> | |
| SUBUNIT | F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has four main subunits: a, b, b' and c. |
| else | |
| SUBUNIT | F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a(1), b(2) and c(9-12). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. CF(1) is attached to CF(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains. |
| end case | |
| case <OG:Chloroplast> | |
| SUBCELLULAR LOCATION | Plastid, chloroplast thylakoid membrane; Peripheral membrane protein. |
| else case <OC:Cyanobacteriota> and not <OC:Gloeobacter> | |
| SUBCELLULAR LOCATION | Cellular thylakoid membrane; Peripheral membrane protein. |
| else case <OC:Gloeobacter> | |
| SUBCELLULAR LOCATION | Cell inner membrane; Peripheral membrane protein. |
| else case not defined <Property:Membrane> or <Property:Membrane=1> | |
| SUBCELLULAR LOCATION | Cell membrane; Peripheral membrane protein. |
| else case <Property:Membrane=2> | |
| SUBCELLULAR LOCATION | Cell inner membrane; Peripheral membrane protein. |
| end case | |
| SIMILARITY | Belongs to the ATPase alpha/beta chains family. |
Keywords
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| ATP synthesis | |
| ATP-binding | |
| CF(1) | |
| Ion transport | |
| Nucleotide-binding | |
| <a href="https://www.uniprot.org/keywords/KW-1278">Translocase</a> | |
| Transport | |
| Hydrogen ion transport | |
| Membrane | |
| case <OG:Chloroplast> or <OC:Cyanobacteriota> and not <OC:Gloeobacter> | |
| Thylakoid | |
| else case <OC:Gloeobacter> | |
| Cell membrane | |
| Cell inner membrane | |
| else case not defined <Property:Membrane> or <Property:Membrane=1> | |
| Cell membrane | |
| else case <Property:Membrane=2> | |
| Cell membrane | |
| Cell inner membrane | |
| end case | |
Gene Ontology
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| GO:0005524; Molecular function:ATP binding | |
| GO:0046933; Molecular function:proton-transporting ATP synthase activity, rotational mechanism | |
| GO:0015986; Biological process:proton motive force-driven ATP synthesis | |
| case <OCellular component:Cyanobacteriota> and not <OC:Gloeobacter> | |
| GO:0042651; Cellular component:thylakoid membrane | |
| else case <OG:Chloroplast> | |
| GO:0009535; Cellular component:chloroplast thylakoid membrane | |
| else; https://www.ebi.ac.uk/QuickGO/term/else | |
| GO:0005886; Cellular component:plasma membrane | |
| end case | |
Cross-references
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| PROSITE | PS00152; ATPASE_ALPHA_BETA; 1; |
| Pfam | PF00006; ATP-synt_ab; 1; |
| Pfam | PF00306; ATP-synt_ab_C; 1; |
| Pfam | PF02874; ATP-synt_ab_N; 1; |
| NCBIfam | TIGR00962; AtpA; 1; |
Features
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| From: ATPA_ECOLI (P0ABB0) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| BINDING | 169 | 176 | /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616" |
G-D-[R,K,S]-[Q,A,K,S,G]-[T,I,C,V]-G-K-[T,S,A] | ||||||||
| SITE | 373 | 373 | /note="Required for activity" | S | ||||||||
Additional information
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| Size range | 481-670 amino acids |
| Related rules |
None |
| Fusion | Nter: None Cter: <Unknown> |
| Comments | The second copy in some of the Burkholderia is quite a bit longer. There is a 250 residue fusion of unknown function in UREPA and UREP2. |