HAMAP rule MF_01359
General rule information
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| Accession | MF_01359 |
| Dates | 18-NOV-2008 (Created)
1-JUN-2023 (Last updated, Version 18) |
| Name | NDH1_NuoCD_1 |
| Scope(s) |
Bacteria Alphaproteobacteria Betaproteobacteria Gammaproteobacteria |
| Template(s) | P33599 (NUOCD_ECOLI); [ Recover all ] |
| Triggered by |
HAMAP; MF_01359 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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| Identifier | NUOCD |
| Protein name | RecName: Full=NADH-quinone oxidoreductase subunit C/D; EC=7.1.1.-; AltName: Full=NADH dehydrogenase I subunit C/D; AltName: Full=NDH-1 subunit C/D; |
| Gene name | Name=nuoC; Synonyms=nuoCD, nuoD; |
Comments
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| FUNCTION | NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. |
| CATALYTIC ACTIVITY | Reaction=a quinone + 5 H(+)(in) + NADH = a quinol + 4 H(+)(out) + NAD(+); Xref=Rhea:RHEA:57888, ChEBI:CHEBI:15378, ChEBI:CHEBI:24646, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945, ChEBI:CHEBI:132124; |
| SUBUNIT | NDH-1 is composed of 13 different subunits. Subunits NuoB, CD, E, F, and G constitute the peripheral sector of the complex. |
| case not defined <Property:Membrane> or <Property:Membrane=1> | |
| SUBCELLULAR LOCATION | Cell membrane; Peripheral membrane protein; Cytoplasmic side. |
| else case <Property:Membrane=2> | |
| SUBCELLULAR LOCATION | Cell inner membrane; Peripheral membrane protein; Cytoplasmic side. |
| end case | |
| SIMILARITY | In the N-terminal section; belongs to the complex I 30 kDa subunit family. |
| SIMILARITY | In the C-terminal section; belongs to the complex I 49 kDa subunit family. |
Keywords
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| case defined <Property:Membrane> and <Property:Membrane=2> | |
| Cell inner membrane | |
| end case | |
| Cell membrane | |
| Membrane | |
| Multifunctional enzyme | |
| NAD | |
| Quinone | |
| Ubiquinone | |
| <a href="https://www.uniprot.org/keywords/KW-1278">Translocase</a> | |
| Transport | |
Gene Ontology
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| GO:0016655; Molecular function:oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor |
| GO:0050136; Molecular function:NADH dehydrogenase (quinone) activity |
| GO:0005886; Cellular component:plasma membrane |
Cross-references
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| PROSITE | PS00542; COMPLEX1_30K; 1; |
| PROSITE | PS00535; COMPLEX1_49K; 1; |
| Pfam | PF00329; Complex1_30kDa; 1; |
| Pfam | PF00346; Complex1_49kDa; 1; |
| NCBIfam | TIGR01961; NuoC_fam; 1; |
| NCBIfam | TIGR01962; NuoD; 1; |
Features
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| From: NUOCD_ECOLI (P33599) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| REGION | Nter | 186 | /note="NADH dehydrogenase I subunit C" | |||||||||
| REGION | 210 | Cter | /note="NADH dehydrogenase I subunit D" | |||||||||
Additional information
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| Size range | 578-608 amino acids |
| Related rules |
MF_01357 MF_01358 MF_01397 |
| Fusion | Nter: MF_01356 (nuoB) Cter: None |
| Comments | This family is specific for the nuoC-nuoD fusion found in the Alpha-, Beta-, Gamma- and some Deltaproteobacteria. The nuoCD fusion protein found in the Aquificae, Bacteroidetes, some other Delta- and Epsilonproteobacteria is different enough that it seems to be another subfamily (MF_01397). The Geobacter, SYNC1 and SYNFM nuoBCD fusion proteins are also members of this family. The individual families are MF_01357 (nuoC) and MF_01358 (nuoD). In many bacteria there are both the individual and fused versions. 14 proteins form the NDH-1 complex in most bacteria, there are at least 15 subunits in cyanobacteria and chloroplasts. PARDE and THET8 are annotated with another nomenclature. |