HAMAP

Accession	MF_01359
Dates	18-NOV-2008 (Created) 19-SEP-2011 (Last updated, Version 10)

Data class

Protein

Predictors

HAMAP; MF_01359; [distribution of match scores in UniProtKB];[seed alignment for MF_01359]

Names

NDH1_NuoCD_1

Identifier

NUOCD

Protein name

RecName: Full=NADH-quinone oxidoreductase subunit C/D; EC=1.6.99.5; AltName: Full=NADH dehydrogenase I subunit C/D; AltName: Full=NDH-1 subunit C/D;

Gene name

nuoC, nuoCD, nuoD

FUNCTION: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity).

CATALYTIC ACTIVITY: NADH + quinone = NAD(+) + quinol.

SUBUNIT: NDH-1 is composed of 13 different subunits. Subunits NuoB, CD, E, F, and G constitute the peripheral sector of the complex (By similarity).

SUBCELLULAR LOCATION: Cell membrane; Peripheral membrane protein; Cytoplasmic side (By similarity).

SUBCELLULAR LOCATION: Cell inner membrane; Peripheral membrane protein; Cytoplasmic side (By similarity).

SIMILARITY: In the N-terminal section; belongs to the complex I 30 kDa subunit family.

SIMILARITY: In the C-terminal section; belongs to the complex I 49 kDa subunit family.

PROSITE	PS00542; COMPLEX1_30K; 1; PS00535; COMPLEX1_49K; 1;
Pfam	PF00329; Complex1_30kDa; 1; PF00346; Complex1_49kDa; 1;
TIGRFAMs	TIGR01961; NuoC_fam; 1; TIGR01962; NuoD; 1;

Cell inner membrane.

Cell membrane, Membrane, Multifunctional enzyme, NAD, Oxidoreductase, Quinone, Ubiquinone, Transport.

GO:0016655; Molecular function: oxidoreductase activity, acting on NADH or NADPH, quinone or similar compound as acceptor.
GO:0050136; Molecular function: NADH dehydrogenase (quinone) activity.
GO:0005886; Cellular component: plasma membrane.

From: NUOCD_ECOLI (P33599)
Key		From		To		Description		Condition		FTGroup
REGION		Nter		186		NADH dehydrogenase I subunit C (By similarity)
REGION		210		Cter		NADH dehydrogenase I subunit D (By similarity)

Size range:	578-608 amino acids
Related UniRules:	MF_01357 (NDHJ); MF_01358 (NDHH); MF_01397 (NUOCD)
Template:	P33599 (NUOCD_ECOLI)
Scope:	Bacteria; Alphaproteobacteria Bacteria; Betaproteobacteria Bacteria; Gammaproteobacteria
Fusion:	Nter: MF_01356 (nuoB); Cter: None
Duplicate:	None
Plasmid encoded:	None
Comments:	This family is specific for the nuoC-nuoD fusion found in the Alpha-, Beta-, Gamma- and some Deltaproteobacteria. The nuoCD fusion protein found in the Aquificae, Bacteroidetes, some other Delta- and Epsilonproteobacteria is different enough that it seems to be another subfamily (MF_01397). The Geobacter, PELCD and SYNFM nuoBCD fusion proteins are also members of this family. The individual families are MF_01357 (nuoC) and MF_01358 (nuoD). In many bacteria there are both the individual and fused versions. 14 proteins form the NDH-1 complex in most bacteria, there are at least 15 subunits in cyanobacteria and chloroplasts. PARDE and THET8 are annotated with another nomenclature.