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HAMAP rule MF_01367

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General rule information [?]

Accession MF_01367
Dates 20-NOV-2006 (Created)
22-SEP-2023 (Last updated, Version 22)
Name Ribosomal_uL14
Scope(s) Bacteria
Archaea
Plastid
Template(s) Q9RXJ2 (RL14_DEIRA); P0ADY3 (RL14_ECOLI); Q5SHP8 (RL14_THET8); P22450 (RL14_HALMA); [ Recover all ]
Triggered by
case c? <OC:Bacteria> or <OC:Archaea> or <OG:Chloroplast>
HAMAP; MF_01367 (Get profile general information and statistics)
end case

Propagated annotation [?]

Identifier, protein and gene names [?]

case <OC:Bacteria> and not <OC:Cyanobacteriota>
Identifier RL14
Protein name RecName: Full=Large ribosomal subunit protein uL14;
Gene name Name=rplN;
else case <OC:Cyanobacteriota>
Identifier RL14
Protein name RecName: Full=Large ribosomal subunit protein uL14;
Gene name Name=rplN; Synonyms=rpl14;
else case <OC:Archaea>
Identifier RL14
Protein name RecName: Full=Large ribosomal subunit protein uL14;
Gene name Name=rpl14;
else case <OG:Chloroplast>
Identifier RK14
Protein name RecName: Full=Large ribosomal subunit protein uL14c;
Gene name Name=rpl14;
end case

Comments [?]

case <OC:Bacteria>
FUNCTIONBinds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome.
SUBUNITPart of the 50S ribosomal subunit. Forms a cluster with proteins L3 and L19. In the 70S ribosome, L14 and L19 interact and together make contacts with the 16S rRNA in bridges B5 and B8.
else case <OC:Archaea>
FUNCTIONBinds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome.
SUBUNITPart of the 50S ribosomal subunit. Forms a cluster with proteins L3 and L24e, part of which may contact the 16S rRNA in 2 intersubunit bridges.
else case <OG:Chloroplast>
FUNCTIONBinds to 23S rRNA.
SUBUNITPart of the 50S ribosomal subunit.
SUBCELLULAR LOCATIONPlastid, chloroplast.
end case
SIMILARITYBelongs to the universal ribosomal protein uL14 family.

Keywords [?]


Gene Ontology [?]

GO:0019843; Molecular function:rRNA binding
GO:0006412; Biological process:translation
case <OG:Chloroplast>
GO:0009507; Cellular component:chloroplast
end case

Cross-references [?]

PROSITE PS00049; RIBOSOMAL_L14; 1;
Pfam PF00238; Ribosomal_L14; 1;
NCBIfam TIGR01067; RplN_bact; 1;
NCBIfam TIGR03673; rpl14p_arch; 1;

Features [?]


Additional information [?]

Size range 119-182 amino acids
Related rules None
Fusion Nter: None Cter: None
Comments In E.coli interaction of L14 with ribosomal silencing factor RsfS has been shown block formation of bridge B8, preventing association of 2 ribosomal subunits and thus causes ribosomal silencing. The same interaction is suspected to have the same effect in human mitochondrial ribosomes and maybe maize chloroplasts as well. It has not yet been propagated to all ribosomal proteins while waiting further experimental confirmation.



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