HAMAP rule MF_01374

General rule information [?]

Accession	MF_01374
Dates	9-OCT-2007 (Created) 1-JUN-2023 (Last updated, Version 14)
Name	Glyoxalase_2
Scope(s)	Bacteria
Template(s)	P0AC84 (GLO2_ECOLI); Q8ZRM2 (GLO2_SALTY); [ Recover all ]
Triggered by	HAMAP; MF_01374 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier	GLO2
Protein name	RecName: Full=Hydroxyacylglutathione hydrolase; EC=3.1.2.6; AltName: Full=Glyoxalase II; Short=Glx II;
Gene name	Name=gloB;

Comments [?]

FUNCTION	Thiolesterase that catalyzes the hydrolysis of S-D-lactoyl- glutathione to form glutathione and D-lactic acid.
CATALYTIC ACTIVITY	Reaction=an S-(2-hydroxyacyl)glutathione + H2O = a 2-hydroxy carboxylate + glutathione + H(+); Xref=Rhea:RHEA:21864, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:57925, ChEBI:CHEBI:58896, ChEBI:CHEBI:71261; EC=3.1.2.6;
COFACTOR	Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Note=Binds 2 Zn(2+) ions per subunit.;
PATHWAY	Secondary metabolite metabolism; methylglyoxal degradation; (R)-lactate from methylglyoxal: step 2/2.
SUBUNIT	Monomer.
SIMILARITY	Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family.

Keywords [?]

Gene Ontology [?]

GO:0004416; Molecular function:hydroxyacylglutathione hydrolase activity

Cross-references [?]

Features [?]

From: GLO2_ECOLI (P0AC84)
Key	From	To	Description	Tag	Condition	FTGroup
BINDING	53	53	/ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="1"		H	1
BINDING	55	55	/ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="1"		H	1
BINDING	57	57	/ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="2"		D	2
BINDING	58	58	/ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="2"		H	2
BINDING	110	110	/ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="1"		H	1
BINDING	127	127	/ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="1"		D	1
BINDING	127	127	/ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="2"		D	2
BINDING	165	165	/ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="2"		H	2

Additional information [?]