HAMAP

Accession	MF_01374
Dates	9-OCT-2007 (Created) 25-NOV-2009 (Last updated, Version 6)

Data class

Protein

Predictors

HAMAP; MF_01374; [distribution of match scores in UniProtKB];[seed alignment for MF_01374]

Names

Glyoxalase_2

Identifier

GLO2

Protein name

RecName: Full=Hydroxyacylglutathione hydrolase; EC=3.1.2.6; AltName: Full=Glyoxalase II; Short=Glx II;

Gene name

gloB

FUNCTION: Thiolesterase that catalyzes the hydrolysis of S-D-lactoyl-glutathione to form glutathione and D-lactic acid (By similarity).

CATALYTIC ACTIVITY: S-(2-hydroxyacyl)glutathione + H(2)O = glutathione + a 2-hydroxy carboxylate.

COFACTOR: Binds 2 zinc ions per subunit (By similarity).

PATHWAY: Secondary metabolite metabolism; methylglyoxal degradation; (R)-lactate from methylglyoxal: step 2/2.

SUBUNIT: Monomer (By similarity).

SIMILARITY: Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family.

Pfam	PF00753; Lactamase_B; 1;

Hydrolase, Metal-binding, Zinc.

GO:0004416; Molecular function: hydroxyacylglutathione hydrolase activity.

From: GLO2_ECOLI (P0AC84)
Key		From		To		Description		Condition		FTGroup
METAL		53		53		Zinc 1 (By similarity)		H		1
METAL		55		55		Zinc 1 (By similarity)		H		1
METAL		57		57		Zinc 2 (By similarity)		D		2
METAL		58		58		Zinc 2 (By similarity)		H		2
METAL		110		110		Zinc 1 (By similarity)		H		1
METAL		127		127		Zinc 1 (By similarity)		D		1
METAL		127		127		Zinc 2 (By similarity)		D		2
METAL		165		165		Zinc 2 (By similarity)		H		2

Size range:	233-272 amino acids
Related UniRules:	None
Template:	P0AC84 (GLO2_ECOLI); Q8ZRM2 (GLO2_SALTY): [Recover all]
Scope:	Bacteria
Fusion:	Nter: None; Cter: None
Duplicate:	in VIBVY
Plasmid encoded:	None