HAMAP rule MF_01377
General rule information
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| Accession | MF_01377 |
| Dates | 4-JUN-2007 (Created)
1-JUN-2023 (Last updated, Version 23) |
| Name | YegS |
| Scope(s) |
Bacteria Gammaproteobacteria |
| Template(s) | P76407 (YEGS_ECOLI); Q8ZNP1 (YEGS_SALTY); [ Recover all ] |
| Triggered by |
HAMAP; MF_01377 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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| Identifier | YEGS |
| case <OC:Escherichia> or <OC:Shigella> or <OC:Salmonella> | |
| Protein name | RecName: Full=Probable lipid kinase YegS; EC=2.7.1.-; |
| Gene name | Name=yegS; |
| else | |
| Protein name | RecName: Full=Probable lipid kinase YegS-like; EC=2.7.1.-; |
| end case | |
Comments
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| FUNCTION | Probably phosphorylates lipids; the in vivo substrate is unknown. |
| COFACTOR | Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Note=Binds 1 Mg(2+) ion per subunit. Ca(2+) may be able to substitute.; |
| SUBCELLULAR LOCATION | Cytoplasm. |
| SIMILARITY | Belongs to the diacylglycerol/lipid kinase family. YegS lipid kinase subfamily. |
Keywords
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| ATP-binding |
| Cytoplasm |
| Kinase |
| Lipid biosynthesis |
| Lipid metabolism |
| Magnesium |
| Metal-binding |
| Nucleotide-binding |
| Phospholipid biosynthesis |
| Phospholipid metabolism |
| Transferase |
Gene Ontology
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| GO:0000287; Molecular function:magnesium ion binding |
| GO:0001727; Molecular function:lipid kinase activity |
| GO:0005524; Molecular function:ATP binding |
| GO:0008654; Biological process:phospholipid biosynthetic process |
| GO:0005737; Cellular component:cytoplasm |
Cross-references
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| Pfam | PF00781; DAGK_cat; 1; |
| NCBIfam | TIGR03702; lip_kinase_YegS; 1; |
| NCBIfam | TIGR00147; TIGR00147; 1; |
| PROSITE | PS50146; DAGK; 1; |
Features
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| From: YEGS_ECOLI (P76407) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| BINDING | 66 | 72 | /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616" |
|||||||||
| ACT_SITE | 271 | 271 | /note="Proton acceptor" | E | ||||||||
| BINDING | 215 | 215 | /ligand="Mg(2+)" /ligand_id="ChEBI:CHEBI:18420" |
[LVKRM] | ||||||||
| BINDING | 218 | 218 | /ligand="Mg(2+)" /ligand_id="ChEBI:CHEBI:18420" |
D | ||||||||
| BINDING | 220 | 220 | /ligand="Mg(2+)" /ligand_id="ChEBI:CHEBI:18420" |
L | ||||||||
| BINDING | 40 | 40 | /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616" |
[TS] | ||||||||
| BINDING | 95 | 95 | /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616" |
[TS] | ||||||||
Additional information
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| Size range | 290-340 amino acids |
| Related rules |
None |
| Fusion | Nter: None Cter: None |