HAMAP

Accession	MF_01381
Dates	12-NOV-2007 (Created) 25-NOV-2009 (Last updated, Version 10)

Data class

Protein

Predictors

HAMAP; MF_01381; [distribution of match scores in UniProtKB];[seed alignment for MF_01381]

Names

EmtA

Identifier

EMTA

Protein name

RecName: Full=Endo-type membrane-bound lytic murein transglycosylase A; EC=4.2.2.n2; AltName: Full=Peptidoglycan lytic endotransglycosylase; Flags: Precursor;

Gene name

emtA

FUNCTION: Murein-degrading enzyme. May play a role in recycling of muropeptides during cell elongation and/or cell division. Preferentially cleaves at a distance of more than two disaccharide units from the ends of the glycan chain (By similarity).

CATALYTIC ACTIVITY: Endolytic cleavage of the (1->4)-beta-glycosidic linkage between N-acetylmuramic acid (MurNAc) and N-acetylglucosamine (GlcNAc) residues in peptidoglycan with concomitant formation of a 1,6-anhydrobond in the MurNAc residue.

SUBCELLULAR LOCATION: Cell outer membrane; Lipid-anchor (Potential).

SIMILARITY: Belongs to the transglycosylase slt family.

PROSITE	PS51257; PROKAR_LIPOPROTEIN; 1; trigger=PRU00303; PS00922; TRANSGLYCOSYLASE; 1;
Pfam	PF01464; SLT; 1;

Cell wall biogenesis/degradation, Lyase, Membrane, Cell membrane, Cell outer membrane, Signal.

Lipoprotein, Palmitate.

GO:0016837; Molecular function: carbon-oxygen lyase activity, acting on polysaccharides.
GO:0016998; Biological process: cell wall macromolecule catabolic process.
GO:0009279; Cellular component: cell outer membrane.

Size range:	203-219 amino acids
Related UniRules:	None
Template:	P0C960 (EMTA_ECOLI)
Scope:	Bacteria; Enterobacteriaceae
Fusion:	Nter: None; Cter: None
Duplicate:	in SHIFL
Plasmid encoded:	None
Comments:	Due to a small duplication there is a second copy in SHIFL 301 / Serotype 2a that does not have a lipobox and is annotated as atypical.