HAMAP rule MF_01384
General rule information
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| Accession | MF_01384 |
| Dates | 8-MAY-2008 (Created)
17-FEB-2023 (Last updated, Version 17) |
| Name | UreD |
| Scope(s) |
Bacteria Actinomycetota Bacteroidota Chloroflexota Cyanobacteriota Deinococcota Bacillota Magnetococcus Pseudomonadota Mycoplasmatota Verrucomicrobiota Archaea |
| Template(s) | Q09063 (URED_KLEAE); P17089 (URED_PROMH); Q9ZFR5 (URED_YERPE); [ Recover all ] |
| Triggered by |
HAMAP; MF_01384 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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| case not <OC:Helicobacter> | |
| Identifier | URED |
| Protein name | RecName: Full=Urease accessory protein UreD; |
| Gene name | Name=ureD; |
| else case <OC:Helicobacter> | |
| Identifier | UREH |
| Protein name | RecName: Full=Urease accessory protein UreH; |
| Gene name | Name=ureH; |
| end case | |
Comments
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| FUNCTION | Required for maturation of urease via the functional incorporation of the urease nickel metallocenter. |
| case not <OC:Helicobacter> | |
| SUBUNIT | UreD, UreF and UreG form a complex that acts as a GTP- hydrolysis-dependent molecular chaperone, activating the urease apoprotein by helping to assemble the nickel containing metallocenter of UreC. The UreE protein probably delivers the nickel. |
| else case <OC:Helicobacter> | |
| SUBUNIT | UreH, UreF and UreG form a complex that acts as a GTP- hydrolysis-dependent molecular chaperone, activating the urease apoprotein by helping to assemble the nickel containing metallocenter of UreC. The UreE protein probably delivers the nickel. |
| end case | |
| SUBCELLULAR LOCATION | Cytoplasm. |
| SIMILARITY | Belongs to the UreD family. |
Keywords
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Gene Ontology
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| GO:0016151; Molecular function:nickel cation binding |
| GO:0005737; Cellular component:cytoplasm |
Cross-references
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| Pfam | PF01774; UreD; 1; |
Features
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Additional information
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| Size range | 240-329 amino acids |
| Related rules |
None |
| Fusion | Nter: None Cter: None |
| Comments | Called ureH in Helicobacter where ureD is an unrelated protein of the urease operon. Some E.coli EHEC strains are urease negative despite the presence of the operon in their genomes; in a few cases this has been shown to be due to nonsense mutations in ureD, for example ECO57. YERPE has a different nonsense mutation and is also non-functional. For some orally acquired pathogens (Brucella, Helicobacter, YERPE) urease acts as a virulence factor. In Brucella there are usually 2 urease operons. |