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HAMAP rule MF_01384

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General rule information [?]

Accession MF_01384
Dates 8-MAY-2008 (Created)
17-FEB-2023 (Last updated, Version 17)
Name UreD
Scope(s) Bacteria
Actinomycetota
Bacteroidota
Chloroflexota
Cyanobacteriota
Deinococcota
Bacillota
Magnetococcus
Pseudomonadota
Mycoplasmatota
Verrucomicrobiota
Archaea
Template(s) Q09063 (URED_KLEAE); P17089 (URED_PROMH); Q9ZFR5 (URED_YERPE); [ Recover all ]
Triggered by HAMAP; MF_01384 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

case not <OC:Helicobacter>
Identifier URED
Protein name RecName: Full=Urease accessory protein UreD;
Gene name Name=ureD;
else case <OC:Helicobacter>
Identifier UREH
Protein name RecName: Full=Urease accessory protein UreH;
Gene name Name=ureH;
end case

Comments [?]

FUNCTIONRequired for maturation of urease via the functional incorporation of the urease nickel metallocenter.
case not <OC:Helicobacter>
SUBUNITUreD, UreF and UreG form a complex that acts as a GTP- hydrolysis-dependent molecular chaperone, activating the urease apoprotein by helping to assemble the nickel containing metallocenter of UreC. The UreE protein probably delivers the nickel.
else case <OC:Helicobacter>
SUBUNITUreH, UreF and UreG form a complex that acts as a GTP- hydrolysis-dependent molecular chaperone, activating the urease apoprotein by helping to assemble the nickel containing metallocenter of UreC. The UreE protein probably delivers the nickel.
end case
SUBCELLULAR LOCATIONCytoplasm.
SIMILARITYBelongs to the UreD family.

Keywords [?]


Gene Ontology [?]

GO:0016151; Molecular function:nickel cation binding
GO:0005737; Cellular component:cytoplasm

Cross-references [?]

Pfam PF01774; UreD; 1;

Features [?]


Additional information [?]

Size range 240-329 amino acids
Related rules None
Fusion Nter: None Cter: None
Comments Called ureH in Helicobacter where ureD is an unrelated protein of the urease operon. Some E.coli EHEC strains are urease negative despite the presence of the operon in their genomes; in a few cases this has been shown to be due to nonsense mutations in ureD, for example ECO57. YERPE has a different nonsense mutation and is also non-functional. For some orally acquired pathogens (Brucella, Helicobacter, YERPE) urease acts as a virulence factor. In Brucella there are usually 2 urease operons.



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