HAMAP

Accession	MF_01385
Dates	19-JUN-2008 (Created) 19-SEP-2011 (Last updated, Version 5)

Data class

Protein

Predictors

HAMAP; MF_01385; [distribution of match scores in UniProtKB];[seed alignment for MF_01385]

Names

UreF

Identifier

UREF

Protein name

RecName: Full=Urease accessory protein UreF;

Gene name

ureF

FUNCTION: Required for maturation of urease via the functional incorporation of the urease nickel metallocenter (By similarity).

SUBUNIT: UreD, UreF and UreG form a complex that acts as a GTP-hydrolysis-dependent molecular chaperone, activating the urease apoprotein by helping to assemble the nickel containing metallocenter of UreC. The UreE protein probably delivers the nickel (By similarity).

SUBUNIT: UreH, UreF and UreG form a complex that acts as a GTP-hydrolysis-dependent molecular chaperone, activating the urease apoprotein by helping to assemble the nickel containing metallocenter of UreC. The UreE protein probably delivers the nickel (By similarity).

SUBCELLULAR LOCATION: Cytoplasm (By similarity).

SIMILARITY: Belongs to the UreF family.

Pfam	PF01730; UreF; 1;

Chaperone, Cytoplasm, Nickel insertion.

GO:0016151; Molecular function: nickel ion binding.
GO:0005737; Cellular component: cytoplasm.

Size range:	205-266 amino acids
Related UniRules:	None
Template:	P18318 (UREF_ENTAE); P17091 (UREF_PROMH); Q09065 (UREF_HELPY): [Recover all]
Scope:	Bacteria
Fusion:	Nter: None; Cter: None
Duplicate:	in BRUA2, BRUAB, BRUC2, BRUME, BRUSI, BRUSU, ECO57, OCHA4, PSESM
Plasmid encoded:	in ECOLX
Comments:	For some orally acquired pathogens (Brucella, YERPE) urease acts as a virulence factor. In Brucella there are usually 2 urease operons.