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HAMAP annotation rule: MF_01393
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General rule information

Accession MF_01393
Dates 28-NOV-2008 (Created)
18-AUG-2010 (Last updated, Version 8)
Data class Protein
Predictors HAMAP; MF_01393; [distribution of match scores in UniProtKB];[seed alignment for MF_01393]
Names ATP_synth_a_bact


Propagated annotation

Identifier, protein and gene names

case <OC:Bacteria>
Identifier ATP6
Protein name
RecName: Full=ATP synthase subunit a;
AltName: Full=ATP synthase F0 sector subunit a;
AltName: Full=F-ATPase subunit 6;

else case <OG:Chloroplast>
Identifier ATPI
Protein name
RecName: Full=ATP synthase subunit a, chloroplastic;
AltName: Full=ATP synthase F0 sector subunit a;
AltName: Full=F-ATPase subunit IV;
end case


case <OC:Cyanobacteria>
Gene name atpB, atpI

else case <OG:Chloroplast>
Gene name atpI

else
Gene name atpB
end case

Comments
FUNCTION: Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane (By similarity).

case <OG:Chloroplast> or <Property:PHOTOSYN>
SUBUNIT: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has four main subunits: a, b, b' and c (By similarity).

else
SUBUNIT: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a(1), b(2) and c(9-12). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. CF(1) is attached to CF(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains (By similarity).
end case


case <OG:Chloroplast>
SUBCELLULAR LOCATION: Plastid, chloroplast thylakoid membrane; Multi-pass membrane protein (By similarity).

else case <OC:Cyanobacteria> and not <OC:Gloeobacter>
SUBCELLULAR LOCATION: Cellular thylakoid membrane; Multi-pass membrane protein (By similarity).

else case <OC:Gloeobacter>
SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein (By similarity).

else case not defined <Property:Membrane> or <Property:Membrane=1>
SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein (By similarity).

else case <Property:Membrane=2>
SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein (By similarity).
end case

SIMILARITY: Belongs to the ATPase A chain family.
Cross-references
PROSITE PS00449; ATPASE_A; 1;
Pfam PF00119; ATP-synt_A; 1;
PRINTS PR00123; ATPASEA; 1;
TIGRFAMs TIGR01131; ATP_synt_6_or_A; 1;
General Transmembrane; -; 4-8; trigger=Yes;
Keywords
ATP synthesis, CF(0), Hydrogen ion transport, Ion transport, Membrane, Transmembrane, Transport.

case <OG:Chloroplast> or <OC:Cyanobacteria> and not <OC:Gloeobacter>
Thylakoid.

else case <OC:Gloeobacter>
Cell membrane, Cell inner membrane.

else case not defined <Property:Membrane> or <Property:Membrane=1>
Cell membrane.

else case <Property:Membrane=2>
Cell membrane, Cell inner membrane.
end case

Transmembrane helix.
Gene Ontology
GO:0046933; Molecular function: hydrogen ion transporting ATP synthase activity, rotational mechanism.
GO:0042777; Biological process: plasma membrane ATP synthesis coupled proton transport.

case <OC:Cyanobacteria> and not <OC:Gloeobacter>
GO:0042651; Cellular component: thylakoid membrane.

else
GO:0005886; Cellular component: plasma membrane.
end case


case <OG:Chloroplast>
GO:0009535; Cellular component: chloroplast thylakoid membrane.
end case



Additional information

Size range: 207-406 amino acids
Related UniRules: None
Template: P0AB98 (ATP6_ECOLI); P06451 (ATPI_SPIOL): [Recover all]
Scope: Bacteria
Plastid
Fusion: Nter: None; Cter: None
Duplicate: in ACAM1, BRASB, CHLP8, CHLTE, CYAA5, HAHCH, METCA, OCHA4, PELCD, PELLD, PELPD, PHOPR, SYNP2, VIBHB
Plasmid encoded: None
Comments: In Anaeromyxobacter and some of the Chlorobi the protein could have a signal sequence; these proteins have a considerably longer N- terminus compared to other family members.

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UniProtKB rule member sequences