HAMAP

Accession	MF_01397
Dates	29-JAN-2009 (Created) 19-SEP-2011 (Last updated, Version 5)

Data class

Protein

Predictors

HAMAP; MF_01397; [distribution of match scores in UniProtKB];[seed alignment for MF_01397]

Names

NDH1_NuoCD_2

Identifier

NUOCD

Protein name

RecName: Full=NADH-quinone oxidoreductase subunit C/D; EC=1.6.99.5; AltName: Full=NADH dehydrogenase I subunit C/D; AltName: Full=NDH-1 subunit C/D; AltName: Full=NUO3/NUO4;

Gene name

nuoC

FUNCTION: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

CATALYTIC ACTIVITY: NADH + quinone = NAD(+) + quinol.

SUBUNIT: NDH-1 is composed of 13 different subunits. Subunits NuoB, CD, E, F, and G constitute the peripheral sector of the complex.

SUBCELLULAR LOCATION: Cell inner membrane; Peripheral membrane protein (By similarity).

SIMILARITY: In the N-terminal section; belongs to the complex I 30 kDa subunit family.

SIMILARITY: In the C-terminal section; belongs to the complex I 49 kDa subunit family.

PROSITE	PS00542; COMPLEX1_30K; 1; PS00535; COMPLEX1_49K; 1;
Pfam	PF00329; Complex1_30kDa; 1; PF00346; Complex1_49kDa; 1;
TIGRFAMs	TIGR01961; NuoC_fam; 1; TIGR01962; NuoD; 1;

Cell inner membrane, Cell membrane, Cytoplasm, Membrane, Multifunctional enzyme, NAD, Oxidoreductase, Quinone, Transport, Ubiquinone.

GO:0016655; Molecular function: oxidoreductase activity, acting on NADH or NADPH, quinone or similar compound as acceptor.
GO:0050136; Molecular function: NADH dehydrogenase (quinone) activity.
GO:0005886; Cellular component: plasma membrane.

From: NUOCD_BDEBA (Q6MIR5)
Key		From		To		Description		Condition		FTGroup
REGION		Nter		157		NADH dehydrogenase I subunit C (By similarity)
REGION		175		Cter		NADH dehydrogenase I subunit D (By similarity)

Size range:	519-593 amino acids
Related UniRules:	MF_01357 (NDHJ); MF_01358 (NDHH); MF_01359 (NUOCD)
Template:	P33599 (NUOCD_ECOLI)
Scope:	Bacteria; Aquificae Bacteria; Bacteroidia Bacteria; Deltaproteobacteria Bacteria; Campylobacteraceae
Fusion:	Nter: None; Cter: None
Duplicate:	in AQUAE
Plasmid encoded:	None
Comments:	This family is specific for the nuoC-nuoD fusion found in Aquificae, Bacteroidetes, Delta-and Epsilonproteobacteria. The nuoCD fusion protein found in the Alpha-, Beta- and Gammaproteobacteria is different enough that it seems to be another subfamily (MF_01359). The individual families are MF_01357 (nuoC) and MF_01358 (nuoD). In many bacteria there are both the individual and fused versions. 14 proteins form the NDH-1 complex in most bacteria, there are at least 15 subunits in cyanobacteria and chloroplasts. PARDE and THET8 are annotated with another nomenclature.