HAMAP annotation rule MF_01397
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Accession MF_01397
Dates 29-JAN-2009 (Created)
14-JAN-2013 (Last updated, Version 6)
Name NDH1_NuoCD_2
Scope Bacteria; Aquificae
Bacteria; Bacteroidia
Bacteria; Deltaproteobacteria
Bacteria; Campylobacteraceae
Triggered by



Identifier
NUOCD
Protein name
RecName: Full=NADH-quinone oxidoreductase subunit C/D;
EC=1.6.99.5;
AltName: Full=NADH dehydrogenase I subunit C/D;
AltName: Full=NDH-1 subunit C/D;
AltName: Full=NUO3/NUO4;
Gene name
nuoC


FUNCTION NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
CATALYTIC ACTIVITY NADH + quinone = NAD(+) + quinol.
SUBUNIT NDH-1 is composed of 13 different subunits. Subunits NuoB, CD, E, F, and G constitute the peripheral sector of the complex.
SUBCELLULAR LOCATION Cell inner membrane; Peripheral membrane protein (By similarity).
SIMILARITY In the N-terminal section; belongs to the complex I 30 kDa subunit family.
In the C-terminal section; belongs to the complex I 49 kDa subunit family.


Cell inner membrane
Cell membrane
Cytoplasm
Membrane
Multifunctional enzyme
NAD
Oxidoreductase
Quinone
Transport
Ubiquinone


GO:0016655; Molecular function: oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor.
GO:0050136; Molecular function: NADH dehydrogenase (quinone) activity.
GO:0005886; Cellular component: plasma membrane.


PROSITE PS00542; COMPLEX1_30K; 1;
PS00535; COMPLEX1_49K; 1;
Pfam PF00329; Complex1_30kDa; 1;
PF00346; Complex1_49kDa; 1;
TIGRFAMs TIGR01961; NuoC_fam; 1;
TIGR01962; NuoD; 1;


From: NUOCD_BDEBA (Q6MIR5)
Key     From     To       Description   Tag   Condition   FTGroup
REGION     Nter     157       NADH dehydrogenase I subunit C (By similarity)        
REGION     175     Cter       NADH dehydrogenase I subunit D (By similarity)        


Size range: 519-593 amino acids
Related Rules: MF_01357 (NDHJ); MF_01358 (NDHH); MF_01359 (NUOCD)
Template: P33599 (NUOCD_ECOLI)
Fusion: None
Comments: This family is specific for the nuoC-nuoD fusion found in Aquificae, Bacteroidetes, Delta-and Epsilonproteobacteria. The nuoCD fusion protein found in the Alpha-, Beta- and Gammaproteobacteria is different enough that it seems to be another subfamily (MF_01359). The individual families are MF_01357 (nuoC) and MF_01358 (nuoD). In many bacteria there are both the individual and fused versions. 14 proteins form the NDH-1 complex in most bacteria, there are at least 15 subunits in cyanobacteria and chloroplasts. PARDE and THET8 are annotated with another nomenclature.


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