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HAMAP annotation rule: MF_01400
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General rule information

Accession MF_01400
Dates 8-APR-2002 (Created)
2-FEB-2011 (Last updated, Version 22)
Data class Protein
Predictors HAMAP; MF_01400; [distribution of match scores in UniProtKB];[seed alignment for MF_01400]
Names MsrB


Propagated annotation

Identifier, protein and gene names
Identifier MSRB
Protein name
RecName: Full=Peptide methionine sulfoxide reductase MsrB;
EC=1.8.4.12;
AltName: Full=Peptide-methionine (R)-S-oxide reductase;
Gene name msrB
Comments
CATALYTIC ACTIVITY: Peptide-L-methionine + thioredoxin disulfide + H(2)O = peptide-L-methionine (R)-S-oxide + thioredoxin.

case <FTGroup:1>
COFACTOR: Binds 1 zinc ion per subunit. The zinc ion is important for the structural integrity of the protein (By similarity).
end case

SIMILARITY: Belongs to the MsrB Met sulfoxide reductase family.
Cross-references
Pfam PF01641; SelR; 1;
TIGRFAMs TIGR00357; MsrB; 1;
Keywords
Oxidoreductase.

case <FTGroup:1>
Metal-binding, Zinc.
end case

Gene Ontology
GO:0008113; Molecular function: peptide-methionine-(S)-S-oxide reductase activity.

case <FTGroup:1>
GO:0008270; Molecular function: zinc ion binding.
end case

Features
From: MSRB_ECOLI (P0A746)
Key     From     To       Description   Condition   FTGroup
ACT_SITE     118     118       Nucleophile (By similarity)   C  
 
METAL (Optional)     46     46       Zinc (By similarity)   C   1
METAL (Optional)     49     49       Zinc (By similarity)   C   1
METAL (Optional)     95     95       Zinc (By similarity)   C   1
METAL (Optional)     98     98       Zinc (By similarity)   C   1


Additional information

Size range: 124-159 amino acids
Related UniRules: None
Template: P14930 (MSRAB_NEIGO); Q9JWM8 (MSRAB_NEIMA); P0A746 (MSRB_ECOLI); Q3JRF0 (MSRB_BURP1); P0A088 (MSRB_STAA8): [Recover all]
Scope: Bacteria
Archaea
Fusion: Nter: MF_01401 (msrA); Cter: MF_01401 (msrA)
Duplicate: in RHIME
Plasmid encoded: in RHIME

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UniProtKB rule member sequences