HAMAP annotation rule MF_01401
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Accession MF_01401
Dates 9-APR-2002 (Created)
31-OCT-2012 (Last updated, Version 24)
Name MsrA
Scope Bacteria
Archaea
Triggered by



Identifier
MSRA
Protein name
RecName: Full=Peptide methionine sulfoxide reductase MsrA;
Short=Protein-methionine-S-oxide reductase;
EC=1.8.4.11;
AltName: Full=Peptide-methionine (S)-S-oxide reductase;
Short=Peptide Met(O) reductase;
Gene name
msrA


FUNCTION Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity).
CATALYTIC ACTIVITY Peptide-L-methionine + thioredoxin disulfide + H(2)O = peptide-L-methionine (S)-S-oxide + thioredoxin.
L-methionine + thioredoxin disulfide + H(2)O = L-methionine (S)-S-oxide + thioredoxin.
SIMILARITY Belongs to the MsrA Met sulfoxide reductase family.


Oxidoreductase


GO:0008113; Molecular function: peptide-methionine (S)-S-oxide reductase activity.
GO:0006464; Biological process: cellular protein modification process.


Pfam PF01625; PMSR; 1;
TIGRFAMs TIGR00401; MsrA; 1;


From: MSRA_ECOLI (P0A744)
Key     From     To       Description   Tag   Condition   FTGroup
ACT_SITE     52     52       By similarity     C  


Size range: 123-222 amino acids
Related Rules: None
Templates: P14930 (MSRAB_NEIGO); Q9JWM8 (MSRAB_NEIMA): [Recover all]
Fusion: Nter: MF_01400 (msrB), <Thioredoxin domain>; Cter: MF_01400 (msrB)


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