HAMAP

Accession	MF_01401
Dates	9-APR-2002 (Created) 2-FEB-2011 (Last updated, Version 21)

Data class

Protein

Predictors

HAMAP; MF_01401; [distribution of match scores in UniProtKB];[seed alignment for MF_01401]

Names

MsrA

Identifier

MSRA

Protein name

RecName: Full=Peptide methionine sulfoxide reductase MsrA; Short=Protein-methionine-S-oxide reductase; EC=1.8.4.11; AltName: Full=Peptide-methionine (S)-S-oxide reductase; Short=Peptide Met(O) reductase;

Gene name

msrA

FUNCTION: Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity).

CATALYTIC ACTIVITY: Peptide-L-methionine + thioredoxin disulfide + H(2)O = peptide-L-methionine (S)-S-oxide + thioredoxin.

CATALYTIC ACTIVITY: L-methionine + thioredoxin disulfide + H(2)O = L-methionine (S)-S-oxide + thioredoxin.

SIMILARITY: Belongs to the MsrA Met sulfoxide reductase family.

Pfam	PF01625; PMSR; 1;
TIGRFAMs	TIGR00401; msrA; 1;

Oxidoreductase.

GO:0008113; Molecular function: peptide-methionine-(S)-S-oxide reductase activity.
GO:0006464; Biological process: protein modification process.

From: MSRA_ECOLI (P0A744)
Key		From		To		Description		Condition		FTGroup
ACT_SITE		52		52		By similarity		C

Size range:	123-222 amino acids
Related UniRules:	None
Template:	P14930 (MSRAB_NEIGO); Q9JWM8 (MSRAB_NEIMA): [Recover all]
Scope:	Bacteria Archaea
Fusion:	Nter: MF_01400 (msrB), <Thioredoxin domain>; Cter: MF_01400 (msrB)
Duplicate:	in NOSS1, CAUCR, LACLA, RHILO, RHIME, RHOBA, STAAU, SYNY3
Plasmid encoded:	in RHIME