HAMAP annotation rule: MF_01401
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Accession MF_01401
Dates 9-APR-2002 (Created)
2-FEB-2011 (Last updated, Version 21)
Data class Protein
Names MsrA



Identifier MSRA
Protein name
RecName: Full=Peptide methionine sulfoxide reductase MsrA;
Short=Protein-methionine-S-oxide reductase;
EC=1.8.4.11;
AltName: Full=Peptide-methionine (S)-S-oxide reductase;
Short=Peptide Met(O) reductase;
Gene name msrA
FUNCTION: Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity).
CATALYTIC ACTIVITY: Peptide-L-methionine + thioredoxin disulfide + H(2)O = peptide-L-methionine (S)-S-oxide + thioredoxin.
CATALYTIC ACTIVITY: L-methionine + thioredoxin disulfide + H(2)O = L-methionine (S)-S-oxide + thioredoxin.
SIMILARITY: Belongs to the MsrA Met sulfoxide reductase family.
Pfam PF01625; PMSR; 1;
TIGRFAMs TIGR00401; msrA; 1;
GO:0008113; Molecular function: peptide-methionine-(S)-S-oxide reductase activity.
GO:0006464; Biological process: protein modification process.
From: MSRA_ECOLI (P0A744)
Key     From     To       Description   Condition   FTGroup
ACT_SITE     52     52       By similarity   C  



Size range: 123-222 amino acids
Related UniRules: None
Template: P14930 (MSRAB_NEIGO); Q9JWM8 (MSRAB_NEIMA): [Recover all]
Scope: Bacteria
Archaea
Fusion: Nter: MF_01400 (msrB), <Thioredoxin domain>; Cter: MF_01400 (msrB)
Duplicate: in NOSS1, CAUCR, LACLA, RHILO, RHIME, RHOBA, STAAU, SYNY3
Plasmid encoded: in RHIME

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