HAMAP

Accession	MF_01405
Dates	8-AUG-2002 (Created) 9-MAY-2011 (Last updated, Version 19)

Data class

Protein

Predictors

HAMAP; MF_01405; [distribution of match scores in UniProtKB];[seed alignment for MF_01405]

Names

Non_canon_purine_NTPase

Identifier

RDGB

Protein name

RecName: Full=dITP/XTP pyrophosphatase; EC=3.6.1.19; AltName: Full=Non-canonical purine NTP pyrophosphatase; AltName: Full=Non-standard purine NTP pyrophosphatase; AltName: Full=Nucleoside-triphosphate diphosphatase; AltName: Full=Nucleoside-triphosphate pyrophosphatase; Short=NTPase;

Gene name

rdgB

Identifier

NTPA

Protein name

RecName: Full=Non-canonical purine NTP pyrophosphatase; EC=3.6.1.19; AltName: Full=Non-standard purine NTP pyrophosphatase; AltName: Full=Nucleoside-triphosphate diphosphatase; AltName: Full=Nucleoside-triphosphate pyrophosphatase; Short=NTPase;

FUNCTION: Pyrophosphatase that hydrolyzes the non-canonical purine nucleotides deoxyinosine triphosphate (dITP) and xanthosine triphosphate (XTP) as well as 2'-deoxy-N-6-hydroxylaminopurine triposphate (dHAPTP) to their respective monophosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity).

FUNCTION: Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP/dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity).

CATALYTIC ACTIVITY: A nucleoside triphosphate + H(2)O = a nucleotide + diphosphate.

COFACTOR: Binds 1 divalent metal cation ion per subunit; can use either magnesium or manganese (By similarity).

SUBUNIT: Homodimer (By similarity).

SIMILARITY: Belongs to the HAM1 NTPase family.

Pfam	PF01725; Ham1p_like; 1;
TIGRFAMs	TIGR00042; Ham1p_like; 1;

Hydrolase, Magnesium, Manganese, Metal-binding, Nucleotide metabolism, Nucleotide-binding.

GO:0047429; Molecular function: nucleoside-triphosphate diphosphatase activity.
GO:0006163; Biological process: purine nucleotide metabolic process.

From: NTPA_PYRHO (O59580)
Key		From		To		Description		Condition		FTGroup
REGION		7		12		Substrate binding (By similarity)		[ST]-x-[NSH]-x-x-K
REGION		65		66		Substrate binding (By similarity)		D-[STA]
METAL		36		36		Magnesium or manganese (By similarity)		[ED]
METAL		65		65		Magnesium or manganese (By similarity)		D
BINDING		143		143		Substrate (By similarity)		[DN]
BINDING		163		163		Substrate (By similarity)		K
BINDING		169		169		Substrate (By similarity)		R

Size range:	178-328 amino acids
Related UniRules:	None
Template:	P52061 (RDGB_ECOLI); Q57679 (NTPA_METJA); O59580 (NTPA_PYRHO): [Recover all]
Scope:	Bacteria Archaea
Fusion:	Nter: MF_00564 (rph), <Unknown>; Cter: None
Duplicate:	None
Plasmid encoded:	None
Comments:	Unknown N-terminal domain in STRA3, STRA5, STRP1, STRP6, STRP8, STRT1, STRT2