HAMAP

Accession	MF_01423
Dates	2-FEB-2005 (Created) 11-OCT-2011 (Last updated, Version 17)

Data class

Protein

Predictors

HAMAP; MF_01423; [distribution of match scores in UniProtKB];[seed alignment for MF_01423]

Names

MdtB

Identifier

MDTB

Protein name

RecName: Full=Multidrug resistance protein MdtB; AltName: Full=Multidrug transporter MdtB;

Gene name

mdtB

FUNCTION: The MdtABC tripartite complex confers resistance against novobiocin and deoxycholate (By similarity).

SUBUNIT: Part of a tripartite efflux system composed of MdtA, MdtB and MdtC. MdtB forms a heteromultimer with MdtC (By similarity).

SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein (Potential).

INDUCTION: The mdtABC operon is transcriptionally activated by BaeR.

SIMILARITY: Belongs to the AcrB/AcrD/AcrF (TC 2.A.6) family.

Pfam	PF00873; ACR_tran; 1;
PRINTS	PR00702; ACRIFLAVINRP; 1;
General	Transmembrane; -; 11-12; trigger=Yes;

Cell membrane, Cell inner membrane, Membrane, Transport, Transmembrane, Transmembrane helix.

GO:0005215; Molecular function: transporter activity.
GO:0005886; Cellular component: plasma membrane.

Size range:	1039-1056 amino acids
Related UniRules:	None
Template:	P76398 (MDTB_ECOLI)
Scope:	Bacteria; Enterobacteriaceae
Fusion:	Nter: None; Cter: None
Duplicate:	None
Plasmid encoded:	None
Comments:	The complete proteome of Shigella flexneri strain 301 does not contain mdtB. The sequence contains an in-frame codon. The authors have checked the sequence and is believed to be correct.