To improve security and privacy, we are moving our web pages and services from HTTP to HTTPS.
To give users of web services time to transition to HTTPS, we will support separate HTTP and HTTPS services until the end of 2017.
From January 2018 most HTTP traffic will be automatically redirected to HTTPS. [more...]
View this page in https
Annotation rule MF_01423
Send feedback

General rule information [?]

Accession MF_01423
Dates 2-FEB-2005 (Created)
19-OCT-2016 (Last updated, Version 20)
Name MdtB
Scope Bacteria; Enterobacterales
Template P76398 (MDTB_ECOLI)

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
MDTB
Protein name
RecName: Full=Multidrug resistance protein MdtB;
AltName: Full=Multidrug transporter MdtB;
Gene name
mdtB

Comments [?]

case <OC:Escherichia>
Function The MdtABC tripartite complex confers resistance against novobiocin and deoxycholate.
end case
Subunit Part of a tripartite efflux system composed of MdtA, MdtB and MdtC. MdtB forms a heteromultimer with MdtC.
Subcellular location Cell inner membrane; Multi-pass membrane protein.
case <OC:Escherichia>
Induction The mdtABC operon is transcriptionally activated by BaeR.
end case
Similarity Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family. MdtB subfamily.

Keywords [?]


Gene Ontology [?]

GO:0005215; Molecular function: transporter activity.
GO:0005886; Cellular component: plasma membrane.

Cross-references [?]

Pfam PF00873; ACR_tran; 1;
PRINTS PR00702; ACRIFLAVINRP; 1;

Computed features [?]

General Transmembrane; -; 11-12; trigger=yes;

Additional information [?]

Size range 1039-1056 amino acids
Related rules None
Fusion None
Comments The complete proteome of Shigella flexneri strain 301 does not contain mdtB. The sequence contains an in-frame codon. The authors have checked the sequence and is believed to be correct.