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HAMAP annotation rule: MF_01425
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General rule information

Accession MF_01425
Dates 14-FEB-2005 (Created)
28-JAN-2011 (Last updated, Version 17)
Data class Protein
Predictors HAMAP; MF_01425; [distribution of match scores in UniProtKB];[seed alignment for MF_01425]
Names Cation-efflux_FieF


Propagated annotation

Identifier, protein and gene names
Identifier FIEF

case <OC:Escherichia>
Protein name
RecName: Full=Ferrous-iron efflux pump FieF;

else
Protein name
RecName: Full=Cation-efflux pump FieF;
end case

Gene name fieF
Comments

case <OC:Escherichia>
FUNCTION: Iron-efflux transporter responsible for iron detoxification. Also able to transport Zn(2+) in a proton-dependent manner (By similarity).

else
FUNCTION: Cation-efflux transporter that may have a role in detoxification (By similarity).
end case

SUBUNIT: Homodimer (By similarity).
SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein (By similarity).
SIMILARITY: Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. FieF subfamily.
Cross-references
Pfam PF01545; Cation_efflux; 1;
TIGRFAMs TIGR01297; CDF; 1;
General Transmembrane; -; 6; trigger=Yes;
Keywords

case <OC:Escherichia>
Ion transport, Iron, Iron transport.
end case

Cell membrane, Cell inner membrane, Membrane, Transport, Transmembrane, Transmembrane helix.
Gene Ontology
GO:0005215; Molecular function: transporter activity.
GO:0005886; Cellular component: plasma membrane.


Additional information

Size range: 298-300 amino acids
Related UniRules: None
Template: P69380 (FIEF_ECOLI)
Scope: Bacteria; Enterobacteriaceae
Fusion: Nter: None; Cter: None
Duplicate: None
Plasmid encoded: None

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UniProtKB rule member sequences