HAMAP rule MF_01429

General rule information [?]

Accession	MF_01429
Dates	27-OCT-2005 (Created) 1-JUN-2023 (Last updated, Version 19)
Name	Fe_S_insert_IscA
Scope(s)	Bacteria Enterobacterales
Template(s)	P0AAC8 (ISCA_ECOLI); [ Recover all ]
Triggered by	HAMAP; MF_01429 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier	ISCA
Protein name	RecName: Full=Iron-binding protein IscA; AltName: Full=Iron-sulfur cluster assembly protein;
Gene name	Name=iscA;

Comments [?]

FUNCTION	Is able to transfer iron-sulfur clusters to apo-ferredoxin. Multiple cycles of [2Fe2S] cluster formation and transfer are observed, suggesting that IscA acts catalytically. Recruits intracellular free iron so as to provide iron for the assembly of transient iron-sulfur cluster in IscU in the presence of IscS, L-cysteine and the thioredoxin reductase system TrxA/TrxB.
case <FTGroup:1>
COFACTOR	Name=Fe cation; Xref=ChEBI:CHEBI:24875; Note=Binds 2 iron ions per dimer. The dimer may bind additional iron ions.;
end case
SUBUNIT	Homodimer; may form tetramers and higher multimers.
SIMILARITY	Belongs to the HesB/IscA family.

Keywords [?]

Gene Ontology [?]

GO:0005506; Molecular function:iron ion binding
case <FTGroup:1>
GO:0016226; Biological process:iron-sulfur cluster assembly
end case

Cross-references [?]

Features [?]

From: ISCA_ECOLI (P0AAC8)

Key

From

Description

Tag

Condition

FTGroup

BINDING

/ligand="Fe cation"
/ligand_id="ChEBI:CHEBI:24875"

BINDING

/ligand="Fe cation"
/ligand_id="ChEBI:CHEBI:24875"

BINDING

101

/ligand="Fe cation"
/ligand_id="ChEBI:CHEBI:24875"

Additional information [?]