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| HAMAP annotation rule: MF_01429 |
| Accession | MF_01429 |
| Dates | 27-OCT-2005 (Created) 2-DEC-2011 (Last updated, Version 10) |
| Data class | Protein |
| Predictors | HAMAP; MF_01429; [distribution of match scores in UniProtKB];[seed alignment for MF_01429] |
| Names | Fe_S_insert_IscA |
| Identifier | ISCA |
| Protein name |
|
| Gene name | iscA |
FUNCTION: Is able to transfer iron-sulfur clusters to apo-ferredoxin. Multiple cycles of [2Fe2S] cluster formation and transfer are observed, suggesting that iscA acts catalytically. Recruits intracellular free iron so as to provide iron for the assembly of transient iron-sulfur cluster in iscU in the presence of iscS, L-cysteine and the thioredoxin reductase system trxA/trxB (By similarity).
case <FTGroup:1>
COFACTOR: Binds 2 iron ions per dimer. The dimer may bind additional iron ions (By similarity).
end case
SUBUNIT: Homodimer; may form tetramers and higher multimers (By similarity).
SIMILARITY: Belongs to the hesB/iscA family.
| Pfam |
PF01521; Fe-S_biosyn; 1; |
| TIGRFAMs |
TIGR00049; HesB_yadR_yfhF; 1; TIGR02011; IscA; 1; |
| PROSITE |
PS01152; HESB; 1; |
Iron.
case <FTGroup:1>
end case
GO:0005506; Molecular function: iron ion binding.
case <FTGroup:1>
GO:0016226; Biological process: iron-sulfur cluster assembly.
end case
| From: ISCA_ECOLI (P0AAC8) | ||||||||||
| Key | From | To | Description | Condition | FTGroup | |||||
| METAL | 35 | 35 | Iron (By similarity) | C | 1 | |||||
| METAL | 99 | 99 | Iron (By similarity) | C | 1 | |||||
| METAL | 101 | 101 | Iron (By similarity) | C | 1 | |||||
| Size range: | 107-107 amino acids |
| Related UniRules: | None |
| Template: | P0AAC8 (ISCA_ECOLI) |
| Scope: | Bacteria; Enterobacteriaceae |
| Fusion: | Nter: None; Cter: None |
| Duplicate: | None |
| Plasmid encoded: | None |
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