HAMAP

Accession	MF_01441
Dates	27-NOV-2006 (Created) 2-DEC-2011 (Last updated, Version 13)

Data class

Protein

Predictors

HAMAP; MF_01441; [distribution of match scores in UniProtKB];[seed alignment for MF_01441]

Names

Dps

Identifier

DPS

Protein name

RecName: Full=DNA protection during starvation protein; EC=1.16.-.-;

Gene name

dps

FUNCTION: During stationary phase, binds the chromosome non-specifically, forming a highly ordered and stable dps-DNA co-crystal within which chromosomal DNA is condensed and protected from diverse damages. It protects DNA from oxidative damage by sequestering intracellular Fe(2+) ion and storing it in the form of Fe(3+) oxyhydroxide mineral, which can be released after reduction. One hydrogen peroxide oxidizes two Fe(2+) ions, which prevents hydroxyl radical production by the Fenton reaction. Dps also protects the cell from UV and gamma irradiation, iron and copper toxicity, thermal stress and acid and base shocks. Also shows a weak catalase activity (By similarity).

FUNCTION: During stationary phase, binds the chromosome non-specifically, forming a highly ordered and stable dps-DNA co-crystal within which chromosomal DNA is condensed and protected from diverse damages. It protects DNA from oxidative damage by sequestering intracellular Fe(2+) ion and storing it in the form of Fe(3+) oxyhydroxide mineral, which can be released after reduction. One hydrogen peroxide oxidizes two Fe(2+) ions, which prevents hydroxyl radical production by the Fenton reaction (By similarity).

CATALYTIC ACTIVITY: 2 Fe(2+) + H(2)O(2) + 2 H(+) = 2 Fe(3+) + 2 H(2)O.

SUBUNIT: Homododecamer. The 12 subunits form a hollow sphere into which the mineral iron core of up to 500 Fe(3+) can be deposited (By similarity).

SUBCELLULAR LOCATION: Cytoplasm, nucleoid (By similarity).

SUBCELLULAR LOCATION: Cytoplasm (By similarity).

SIMILARITY: Belongs to the dps family.

PROSITE	PS00818; DPS_1; 1; PS00819; DPS_2; 1;
Pfam	PF00210; Ferritin; 1;
PRINTS	PR01346; HELNAPAPROT; 1;

Cytoplasm, DNA condensation, DNA-binding, Iron, Iron storage, Metal-binding, Oxidoreductase.

GO:0008199; Molecular function: ferric iron binding.
GO:0003677; Molecular function: DNA binding.
GO:0016491; Molecular function: oxidoreductase activity.
GO:0005737; Cellular component: cytoplasm.

From: DPS_ECOLI (P0ABT2)
Key		From		To		Description		Condition		FTGroup
METAL		51		51		Iron 1; shared with neighboring subunit (By similarity)		H
METAL		78		78		Iron 1 (By similarity)		D
METAL		82		82		Iron 1 (By similarity)		E
METAL		82		82		Iron 2 (By similarity)		E

Key		From		To		Description		Condition		FTGroup
METAL		51		51		Iron (By similarity)		H
METAL		78		78		Iron (By similarity)		D
METAL		82		82		Iron (By similarity)		E

Size range:	166-169 amino acids
Related UniRules:	None
Template:	P0ABT2 (DPS_ECOLI)
Scope:	Bacteria; Gammaproteobacteria
Fusion:	Nter: None; Cter: None
Duplicate:	None
Plasmid encoded:	None