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HAMAP annotation rule: MF_01446
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General rule information

Accession MF_01446
Dates 13-AUG-2007 (Created)
25-MAR-2011 (Last updated, Version 7)
Data class Protein
Predictors HAMAP; MF_01446; [distribution of match scores in UniProtKB];[seed alignment for MF_01446]
Names Kae1_arch


Propagated annotation

Identifier, protein and gene names
Identifier KAE1
Protein name
RecName: Full=Probable tRNA threonylcarbamoyladenosine biosynthesis protein KAE1 homolog;
AltName: Full=t(6)A37 threonylcarbamoyladenosine biosynthesis protein KAE1 homolog;
Comments
FUNCTION: Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity).
SUBCELLULAR LOCATION: Cytoplasm (Potential).
SIMILARITY: Belongs to the KAE1 / YgjD family.
Cross-references
PROSITE PS01016; GLYCOPROTEASE; 1;
Pfam PF00814; Peptidase_M22; 1;
PRINTS PR00789; OSIALOPTASE; 1;
TIGRFAMs TIGR03722; Arch_KAE1; 1;
TIGR00329; gcp; 1;
Keywords
Cytoplasm.

case <FTGroup:1>
Iron, Metal-binding.
end case

tRNA processing.
Gene Ontology

case <FTGroup:1>
GO:0005506; Molecular function: iron ion binding.
end case

GO:0070526; Biological process: threonylcarbamoyladenosine biosynthetic process.
GO:0005737; Cellular component: cytoplasm.
Features
From: KAE1_PYRAB (Q9UXT7)
Key     From     To       Description   Condition   FTGroup
METAL (Optional)     107     107       Iron (By similarity)   H   1
METAL (Optional)     111     111       Iron (By similarity)   H   1
METAL (Optional)     127     127       Iron (By similarity)   Y   1
METAL (Optional)     285     285       Iron (By similarity)   D   1


Additional information

Size range: 314-363 amino acids
Related UniRules: MF_01447 (KAE1B (supersedes the current rule))
Template: Q9UXT7 (KAE1_PYRAB); P36132 (KAE1_YEAST): [Recover all]
Scope: Archaea
Fusion: Nter: None; Cter: None
Duplicate: None
Plasmid encoded: None
Comments: Was originally (PubMed:17766251) thought to have endonuclease activity, but it could not be confirmed with orthologs purified from M. jannaschii (PubMed:18951093) and S. cerevisiae (PubMed:21183954). Some Archaea contain a kinase domain in the C-terminus. These sequences are represented in the MF_01447 family rule.

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UniProtKB rule member sequences