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HAMAP annotation rule: MF_01447
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General rule information

Accession MF_01447
Dates 13-AUG-2007 (Created)
28-MAR-2011 (Last updated, Version 7)
Data class Protein
Predictors HAMAP; MF_01447; [distribution of match scores in UniProtKB];[seed alignment for MF_01447]
Names Kae1_Bud32_arch


Propagated annotation

Identifier, protein and gene names
Identifier KAE1B
Protein name
RecName: Full=Probable bifunctional tRNA threonylcarbamoyladenosine biosynthesis protein;
RecName: Full=Probable tRNA threonylcarbamoyladenosine biosynthesis protein KAE1 homolog;
AltName: Full=t(6)A37 threonylcarbamoyladenosine biosynthesis protein KAE1 homolog;
RecName: Full=Probable serine/threonine-protein kinase BUD32 homolog;
EC=2.7.11.1;
Comments
FUNCTION: Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity).
CATALYTIC ACTIVITY: ATP + a protein = ADP + a phosphoprotein.
SUBCELLULAR LOCATION: Cytoplasm (Potential).
SIMILARITY: In the N-terminal section; belongs to the KAE1 / YgjD family.
SIMILARITY: In the C-terminal section; belongs to the protein kinase superfamily. Tyr protein kinase family. BUD32 subfamily.
SIMILARITY: Contains 1 protein kinase domain.
Cross-references
PROSITE PS01016; GLYCOPROTEASE; 1;
PS00107; PROTEIN_KINASE_ATP; 1;
PS50011; PROTEIN_KINASE_DOM; 1;
PS00109; PROTEIN_KINASE_TYR; 1;
Pfam PF00814; Peptidase_M22; 1;
PF00069; Pkinase; 1;
PF01163; RIO1; 1;
PRINTS PR00789; OSIALOPTASE; 1;
TIGRFAMs TIGR03724; Arch_bud32; 1;
TIGR03722; Arch_KAE1; 1;
TIGR00329; gcp; 1;
PIRSF PIRSF036401; Gcp_STYKS; 1;
Keywords
ATP-binding, Cytoplasm, Kinase, Nucleotide-binding, Serine/threonine-protein kinase, Transferase, tRNA processing.

case <FTGroup:1>
Iron, Metal-binding.
end case

Gene Ontology

case <FTGroup:1>
GO:0005506; Molecular function: iron ion binding.
end case

GO:0004712; Molecular function: protein serine/threonine/tyrosine kinase activity.
GO:0005524; Molecular function: ATP binding.
GO:0070526; Biological process: threonylcarbamoyladenosine biosynthetic process.
GO:0005737; Cellular component: cytoplasm.
Features
From: KAE1B_METJA (Q58530)
Key     From     To       Description   Condition   FTGroup
DOMAIN     333     Cter       Protein kinase      
NP_BIND     339     347       ATP (By similarity)      
REGION     Nter     323       Kae1      
ACT_SITE     451     451       Proton acceptor (By similarity)   D  
 
METAL (Optional)     106     106       Iron (By similarity)   H   1
METAL (Optional)     110     110       Iron (By similarity)   H   1
METAL (Optional)     127     127       Iron (By similarity)   Y   1
METAL (Optional)     284     284       Iron (By similarity)   D   1
 
BINDING     360     360       ATP (By similarity)   K  


Additional information

Size range: 520-548 amino acids
Related UniRules: MF_01446 (KAE1)
Template: Q58530 (KAE1B_METJA); P36132 (KAE1_YEAST): [Recover all]
Scope: Archaea
Fusion: Nter: None; Cter: None
Duplicate: None
Plasmid encoded: None

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UniProtKB rule member sequences