HAMAP

Accession	MF_01451
Dates	4-JUN-2009 (Created) 18-AUG-2010 (Last updated, Version 7)

Data class

Protein

Predictors

HAMAP; MF_01451; [distribution of match scores in UniProtKB];[seed alignment for MF_01451]

Names

AddA

Identifier

ADDA

Protein name

RecName: Full=ATP-dependent helicase/nuclease subunit A; EC=3.1.-.-; EC=3.6.4.12; AltName: Full=ATP-dependent helicase/nuclease AddA;

Gene name

addA

FUNCTION: The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation; this subunit has the helicase and 3' -> 5' nuclease activities (By similarity).

CATALYTIC ACTIVITY: ATP + H(2)O = ADP + phosphate.

COFACTOR: Magnesium (By similarity).

SUBUNIT: Heterodimer of AddA and AddB/RexB (By similarity).

SIMILARITY: Belongs to the helicase family. AddA subfamily.

PROSITE	PS51198; UVRD_HELICASE_ATP_BIND; 1; trigger=PRU00560; PS51217; UVRD_HELICASE_CTER; 1; trigger=PRU00617;
Pfam	PF00580; UvrD-helicase; 1;
TIGRFAMs	TIGR02785; addA_Gpos; 1;

ATP-binding, DNA damage, DNA repair, DNA-binding, Exonuclease, Helicase, Hydrolase, Nuclease, Nucleotide-binding.

GO:0004003; Molecular function: ATP-dependent DNA helicase activity.
GO:0005524; Molecular function: ATP binding.
GO:0008408; Molecular function: 3'-5' exonuclease activity.
GO:0003690; Molecular function: double-stranded DNA binding.
GO:0000724; Biological process: double-strand break repair via homologous recombination.

Size range:	1167-1405 amino acids
Related UniRules:	None
Template:	P23478 (ADDA_BACSU); A2RH77 (ADDA_LACLM); Q97QP9 (ADDA_STRPN): [Recover all]
Scope:	Bacteria; Firmicutes
Fusion:	Nter: None; Cter: None
Duplicate:	None
Plasmid encoded:	None
Comments:	Originally called rexA in Lactobacillus and Streptococcus. Forms a heterodimer with 1 of 2 related proteins; in Bacillus and Staphylococcus the partner is addB, in Lactobacillus and Streptococcus the partner is rexB.