HAMAP

Accession	MF_01454
Dates	3-SEP-2009 (Created) 17-FEB-2010 (Last updated, Version 4)

Data class

Protein

Predictors

HAMAP; MF_01454; [distribution of match scores in UniProtKB];[seed alignment for MF_01454]

Names

GTPase_Obg

Identifier

OBG

Protein name

RecName: Full=GTPase obg; AltName: Full=GTP-binding protein obg;

Gene name

obg

FUNCTION: An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control (Potential).

COFACTOR: Magnesium (Potential).

SUBUNIT: Monomer (By similarity).

SUBCELLULAR LOCATION: Cytoplasm (By similarity).

SIMILARITY: Belongs to the GTP1/OBG family.

PROSITE	PS00905; GTP1_OBG; 1;
Pfam	PF01018; GTP1_OBG; 1;
PRINTS	PR00326; GTP1OBG; 1;
TIGRFAMs	TIGR02729; Obg_CgtA; 1; TIGR00231; small_GTP; 1; TIGR03595; Obg_CgtA_exten; 1;
PIRSF	PIRSF002401; GTP_bd_Obg/CgtA; 1;

Cytoplasm, GTP-binding, Nucleotide-binding.

GO:0005525; Molecular function: GTP binding.
GO:0003924; Molecular function: GTPase activity.
GO:0005737; Cellular component: cytoplasm.

From: OBG_ECOLI (P42641)
Key		From		To		Description		Condition		FTGroup
NP_BIND		166		173		GTP (By similarity)		G-[FIKLMPRVY]-[PS]-[NS]-[ACSTV]-G-[KR]-S
NP_BIND		213		217		GTP (By similarity)		[DE]-[ILMV]-P-[GS]-[FILV]
NP_BIND		283		286		GTP (By similarity)		[NST]-[KQR]-x-[DE]

Size range:	326-534 amino acids
Related UniRules:	None
Template:	P42641 (OBG_ECOLI); P20964 (OBG_BACSU); B8GYI7 (OBG_CAUCN); Q6E0U3 (OBG_VIBHA); P95722 (OBG_STRCO): [Recover all]
Scope:	Bacteria
Fusion:	Nter: None; Cter: <Radical SAM domain>
Duplicate:	in ANAMF, ANAMM
Plasmid encoded:	in RHOS5
Comments:	BRAHW is C-terminally fused to a radical SAM-type domain. It has been noted that "The C-terminal domains of these proteins, however, can vary in both length and sequence, which may result in functional differences between distantly related bacteria." PubMed:15554976