HAMAP

Accession	MF_01456
Dates	12-NOV-2009 (Created) 6-OCT-2011 (Last updated, Version 9)

Data class

Protein

Predictors

HAMAP; MF_01456; [distribution of match scores in UniProtKB];[seed alignment for MF_01456]

Names

NDH1_NuoK

Identifier

NU4LC

Protein name

RecName: Full=NAD(P)H-quinone oxidoreductase subunit 4L, chloroplastic; EC=1.6.5.-; AltName: Full=NAD(P)H dehydrogenase subunit 4L; AltName: Full=NADH-plastoquinone oxidoreductase subunit 4L;

Gene name

ndhE

Identifier

NU4LC

Protein name

RecName: Full=NAD(P)H-quinone oxidoreductase subunit 4L; EC=1.6.5.-; AltName: Full=NAD(P)H dehydrogenase subunit 4L; AltName: Full=NADH-plastoquinone oxidoreductase subunit 4L; AltName: Full=NDH-1, subunit 4L; AltName: Full=NDH-E;

Gene name

ndhE

Identifier

NUOK

Protein name

RecName: Full=NADH-quinone oxidoreductase subunit K; EC=1.6.99.5; AltName: Full=NADH dehydrogenase I subunit K; AltName: Full=NDH-1 subunit K;

Gene name

nuoK

FUNCTION: NDH shuttles electrons from NAD(P)H:plastoquinone, via FMN and iron-sulfur (Fe-S) centers, to quinones in the photosynthetic chain and possibly in a chloroplast respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation, and thus conserves the redox energy in a proton gradient (By similarity).

FUNCTION: NDH-1 shuttles electrons from an unknown electron donor, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory and/or the photosynthetic chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation, and thus conserves the redox energy in a proton gradient. Cyanobacterial NDH-1 also plays a role in inorganic carbon-concentration (By similarity).

FUNCTION: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity).

FUNCTION: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity).

CATALYTIC ACTIVITY: NAD(P)H + plastoquinone = NAD(P)(+) + plastoquinol.

CATALYTIC ACTIVITY: NADH + quinone = NAD(+) + quinol.

SUBUNIT: NDH is composed of at least 16 different subunits, 5 of which are encoded in the nucleus (By similarity).

SUBUNIT: NDH-1 can be composed of about 15 different subunits; different subcomplexes with different compositions have been identified which probably have different functions (By similarity).

SUBUNIT: NDH-1 is composed of 13 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex (By similarity).

SUBUNIT: NDH-1 is composed of 15 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex (By similarity).

SUBUNIT: NDH-1 is composed of 14 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex (By similarity).

SUBCELLULAR LOCATION: Plastid, chloroplast thylakoid membrane; Multi-pass membrane protein (By similarity).

SUBCELLULAR LOCATION: Cellular thylakoid membrane; Multi-pass membrane protein (By similarity).

SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein (By similarity).

SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein (By similarity).

SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein (By similarity).

SIMILARITY: Belongs to the complex I subunit 4L family.

Pfam	PF00420; Oxidored_q2; 1;
General	Transmembrane; -; 3; trigger=Yes;

NAD.

NADP, Plastoquinone.

Ubiquinone.

Oxidoreductase, Quinone, Membrane, Transmembrane, Transport.

Thylakoid.

Cell membrane, Cell inner membrane.

Cell membrane.

Cell membrane, Cell inner membrane.

Transmembrane helix.

GO:0055114; Biological process: oxidation-reduction process.
GO:0019684; Biological process: photosynthesis, light reaction.

GO:0016655; Molecular function: oxidoreductase activity, acting on NADH or NADPH, quinone or similar compound as acceptor.

GO:0050136; Molecular function: NADH dehydrogenase (quinone) activity.

GO:0042651; Cellular component: thylakoid membrane.

GO:0009535; Cellular component: chloroplast thylakoid membrane.

GO:0005886; Cellular component: plasma membrane.

Size range:	93-148 amino acids
Related UniRules:	None
Template:	P0AFE4 (NUOK_ECOLI); Q56226 (NQO11_THET8); P29923 (NQO11_PARDE): [Recover all]
Scope:	Bacteria Plastid
Fusion:	Nter: None; Cter: None
Duplicate:	in KORVE, AQUAE, GEOBB, GEOMG, GEOSF, GEOSL, GEOSM, GEOUR, RHIE6, RHIEC, RHIME, RHISN, RHOPA, SINMW, SOLUE, STRAW, STRCO, STRGG, SYMTH, SYNFM
Plasmid encoded:	in RHIME, SINMW
Comments:	14 proteins form the NDH-1 complex in most bacteria, there are at least 15 subunits in cyanobacteria and chloroplasts. PARDE and THET8 are annotated with another nomenclature.