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HAMAP rule MF_01463

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General rule information [?]

Accession MF_01463
Dates 5-JUL-2011 (Created)
1-JUN-2023 (Last updated, Version 10)
Name SecD
Scope(s) Bacteria
Archaea
Template(s) P0AG90 (SECD_ECOLI); Q5SKE6 (SECDF_THET8); E9RGS3 (SECD_VIBAL); D4GTK5 (SECD_HALVD); O32047 (SECDF_BACSU); [ Recover all ]
Triggered by
case c? <OC:Bacteria>
HAMAP; MF_01463_B (Get profile general information and statistics)
end case
case c? <OC:Archaea>
HAMAP; MF_01463_A (Get profile general information and statistics)
end case

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier SECD
case <OC:Bacteria>
RecName: Full=Protein translocase subunit SecD;
else case <OC:Archaea>
Protein name RecName: Full=Protein-export membrane protein SecD;
end case
Gene name Name=secD;

Comments [?]

case <OC:Bacteria>
FUNCTIONPart of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA.
else case <OC:Archaea>
FUNCTIONInvolved in protein export.
end case
case <OC:Cyanobacteriota> and not <OC:Gloeobacter>
FUNCTIONProbably participates in protein translocation into and across both the cytoplasmic and thylakoid membranes in cyanobacterial cells.
end case
case <OC:Pseudomonadota>
SUBUNITForms a complex with SecF. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF-YajC and YidC.
else case <OC:Bacteria>
SUBUNITForms a complex with SecF. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved.
else case <OC:Archaea>
SUBUNITPart of the protein translocation apparatus. Forms a complex with SecF.
end case
case not defined <Property:Membrane> or <Property:Membrane=1>
SUBCELLULAR LOCATIONCell membrane; Multi-pass membrane protein.
else case <Property:Membrane=2>
SUBCELLULAR LOCATIONCell inner membrane; Multi-pass membrane protein.
end case
SIMILARITYBelongs to the SecD/SecF family. SecD subfamily.

Keywords [?]

case defined <Property:Membrane> and <Property:Membrane=2>
Cell inner membrane
end case
Cell membrane
Membrane
Protein transport
Translocation
Transmembrane
Transmembrane helix
Transport

Gene Ontology [?]

GO:0065002; Biological process:intracellular protein transmembrane transport
GO:0006605; Biological process:protein targeting
case <OCellular component:Bacteria>
GO:0043952; Biological process:protein transport by the Sec complex
end case
GO:0005886; Cellular component:plasma membrane

Cross-references [?]

Pfam PF07549; Sec_GG; 1;
Pfam PF02355; SecD_SecF; 1;
PRINTS PR01755; SECFTRNLCASE; 1;
NCBIfam TIGR00916; 2A0604s01; 1;
NCBIfam TIGR01129; SecD; 1;
General Transmembrane; -; 6;

Features [?]


Additional information [?]

Size range 385-570 amino acids
Related rules MF_01464
Fusion Nter: None Cter: MF_01464 (SecF)
Comments Often found as a SecDF fusion protein. In bacteria the operon consists of secDF. Some archaea have a secFD operon, in others the genes are separated on the genome.



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