HAMAP rule MF_01465
General rule information
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| Accession | MF_01465 |
| Dates | 18-OCT-2011 (Created)
1-JUN-2023 (Last updated, Version 9) |
| Name | SecY |
| Scope(s) |
Bacteria Archaea Plastid |
| Template(s) | Q60175 (SECY_METJA); O66491 (SECY_AQUAE); P0AGA2 (SECY_ECOLI); Q5SHQ8 (SECY_THET8); Q8U019 (SECY_PYRFU); Q9X1I9 (SECY_THEMA); [ Recover all ] |
| Triggered by |
case c? <OC:Bacteria> or <OC:Archaea> or <OG:Chloroplast>
HAMAP; MF_01465 (Get profile general information and statistics) end case
|
Propagated annotation
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Identifier, protein and gene names
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| Identifier | SECY |
| case <OC:Bacteria> or <OG:Chloroplast> | |
| RecName: Full=Protein translocase subunit SecY; | |
| else case <OC:Archaea> | |
| RecName: Full=Protein translocase subunit SecY;<br /> AltName: Full=Protein transport protein SEC61 subunit alpha homolog; | |
| end case | |
| Gene name | Name=secY; |
Comments
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| case <OC:Bacteria> or <OC:Archaea> | |
| FUNCTION | The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently. |
| else case <OG:Chloroplast> | |
| FUNCTION | The central subunit of the protein translocation channel SecYE. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. |
| end case | |
| case <OC:Bacteria> | |
| SUBUNIT | Component of the Sec protein translocase complex. Heterotrimer consisting of SecY, SecE and SecG subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. Interacts with SecDF, and other proteins may be involved. Interacts with SecA. |
| else case <OC:Archaea> | |
| SUBUNIT | Component of the Sec protein translocase complex. Heterotrimer consisting of alpha (SecY), beta (SecG) and gamma (SecE) subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. May interact with SecDF, and other proteins may be involved. |
| else case <OG:Chloroplast> | |
| SUBUNIT | Component of the plastid Sec protein translocase complex, which is composed of at least SecY and SecE. |
| end case | |
| case <OG:Chloroplast> | |
| SUBCELLULAR LOCATION | Plastid, chloroplast thylakoid membrane; Multi- pass membrane protein. |
| else case <OC:Cyanobacteriota> and not <OC:Gloeobacter> | |
| SUBCELLULAR LOCATION | Cell inner membrane; Multi-pass membrane protein. Cellular thylakoid membrane; Multi-pass membrane protein. |
| else case <OC:Gloeobacter> | |
| SUBCELLULAR LOCATION | Cell inner membrane; Multi-pass membrane protein. |
| else case not defined <Property:Membrane> or <Property:Membrane=1> | |
| SUBCELLULAR LOCATION | Cell membrane; Multi-pass membrane protein. |
| else case <Property:Membrane=2> | |
| SUBCELLULAR LOCATION | Cell inner membrane; Multi-pass membrane protein. |
| end case | |
| SIMILARITY | Belongs to the SecY/SEC61-alpha family. |
Keywords
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| case <OG:Chloroplast> | |
| Thylakoid | |
| else case <OC:Cyanobacteriota> and not <OC:Gloeobacter> | |
| Cell membrane | |
| Cell inner membrane | |
| Thylakoid | |
| else case <OC:Gloeobacter> | |
| Cell membrane | |
| Cell inner membrane | |
| else case not defined <Property:Membrane> or <Property:Membrane=1> | |
| Cell membrane | |
| else case <Property:Membrane=2> | |
| Cell membrane | |
| Cell inner membrane | |
| end case | |
| Membrane | |
| Protein transport | |
| Translocation | |
| Transmembrane | |
| Transmembrane helix | |
| Transport | |
Gene Ontology
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| GO:0065002; Biological process:intracellular protein transmembrane transport | |
| GO:0006605; Biological process:protein targeting | |
| case <OCellular component:Bacteria> | |
| GO:0043952; Biological process:protein transport by the Sec complex | |
| end case | |
| case <OCellular component:Cyanobacteriota> and not <OC:Gloeobacter> | |
| GO:0042651; Cellular component:thylakoid membrane | |
| else case <OG:Chloroplast> | |
| GO:0009535; Cellular component:chloroplast thylakoid membrane | |
| else; https://www.ebi.ac.uk/QuickGO/term/else | |
| GO:0005886; Cellular component:plasma membrane | |
| end case | |
Cross-references
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| PROSITE | PS00755; SECY_1; 1; |
| PROSITE | PS00756; SECY_2; 1; |
| Pfam | PF10559; Plug_translocon; 1; |
| Pfam | PF00344; SecY; 1; |
| PRINTS | PR00303; SECYTRNLCASE; 1; |
| NCBIfam | TIGR00967; 3a0501s007; 1; |
| PIRSF | PIRSF004557; SecY; 1; |
| General | Transmembrane; -; 10; |
Features
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Additional information
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| Size range | 340-661 amino acids |
| Related rules |
MF_01466 |
| Fusion | Nter: None Cter: None |
| Comments | Unless there is a crystal structure we do not usually try to annotate the discontinuous transmembrane helix 2. A second, related SecY2 is encoded in some Staphylococcus and Streptococcus genomes (MF_01466); it is required for export of a large cell wall protein in the few organisms where it has been characterized. The 2 familes, while related, do not overlap. |