 |
|
| HAMAP annotation rule MF_01467 |
| Accession |
MF_01467 |
| Dates |
15-DEC-2011 (Created)
3-JAN-2012 (Last updated, Version 2) |
| Name |
Hypx_phosphoribosyltr |
| Scope |
Archaea; Euryarchaeota |
case not <OC:Halobacteria>
| Protein name |
|
RecName:
|
Full=Hypoxanthine/guanine phosphoribosyltransferase;
|
|
|
Short=HGPRTase;
|
|
|
EC=2.4.2.8;
|
|
else case <OC:Halobacteria>
| Protein name |
|
RecName:
|
Full=HGPRTase-like protein;
|
|
|
EC=2.4.2.-;
|
|
end case
case not <OC:Halobacteria>
| FUNCTION |
Catalyzes a salvage reaction resulting in the formation of IMP that is energically less costly than de novo synthesis (By similarity). |
| CATALYTIC ACTIVITY |
IMP + diphosphate = hypoxanthine + 5-phospho-alpha-D-ribose 1-diphosphate. |
|
GMP + diphosphate = guanine + 5-phospho-alpha-D-ribose 1-diphosphate. |
| PATHWAY |
Purine metabolism; IMP biosynthesis via salvage pathway; IMP from hypoxanthine; step 1/1. |
| SUBUNIT |
Homodimer (By similarity). |
| SUBCELLULAR LOCATION |
Cytoplasm (By similarity). |
else case <OC:Halobacteria>
| FUNCTION |
May catalyze a purine salvage reaction, the substrate is unknown (Potential). |
end case
| SIMILARITY |
Belongs to the purine/pyrimidine phosphoribosyltransferase family. Archaeal HPRT subfamily. |
case not <OC:Halobacteria>
end case
case not <OC:Halobacteria>
GO:0004422; Molecular function: hypoxanthine phosphoribosyltransferase activity.
GO:0043103; Biological process: hypoxanthine salvage.
GO:0005737; Cellular component: cytoplasm.
end case
| PROSITE |
PS00103; PUR_PYR_PR_TRANSFER; 1; |
| Pfam |
PF00156; Pribosyltran; 1; |
| Size range: |
181-196 amino acids |
| Related Rules: |
None |
| Template: |
O33174 (HPRT_METTM) |
| Fusion: |
None |
| Comments: |
Halobacteria are known to have both hypoxanthine/guanine and adenine phosphoribosyltransferase activities; therefore we do not know what is the substrate for this enzyme is in Halobacteria. |