HAMAP rule MF_01471
General rule information
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| Accession | MF_01471 |
| Dates | 26-APR-2012 (Created)
1-JUN-2023 (Last updated, Version 12) |
| Name | Cas2 |
| Scope(s) |
Bacteria Archaea |
| Template(s) | Q97YC2 (CAS2A_SACS2); Q82W51 (CAS2C_NITEU); Q9X2B6 (CAS2_THEMA); O28403 (CAS2A_ARCFU); O27155 (CAS2_METTH); Q97Y85 (CAS2B_SACS2); [ Recover all ] |
| Triggered by |
HAMAP; MF_01471 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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| Identifier | CAS2 |
| Protein name | RecName: Full=CRISPR-associated endoribonuclease Cas2; EC=3.1.-.-; |
| Gene name | Name=cas2; |
Comments
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| FUNCTION | CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette. |
| case <FT:1> | |
| COFACTOR | Name=Mg(2+); Xref=ChEBI:CHEBI:18420; |
| end case | |
| SUBUNIT | Homodimer, forms a heterotetramer with a Cas1 homodimer. |
| SIMILARITY | Belongs to the CRISPR-associated endoribonuclease Cas2 protein family. |
Keywords
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| Antiviral defense | |
| Endonuclease | |
| Hydrolase | |
| case <FT:1> | |
| Magnesium | |
| Metal-binding | |
| end case | |
| Nuclease | |
Gene Ontology
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| GO:0004519; Molecular function:endonuclease activity | |
| case <FT:1> | |
| GO:0046872; Molecular function:metal ion binding | |
| end case | |
| GO:0051607; Biological process:defense response to virus | |
| GO:0043571; Biological process:maintenance of CRISPR repeat elements | |
Cross-references
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Features
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| From: CAS2A_SACS2 (Q97YC2) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| BINDING | 10 | 10 | /ligand="Mg(2+)" /ligand_id="ChEBI:CHEBI:18420" /ligand_note="catalytic" |
[DE] | ||||||||
Additional information
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| Size range | 85-143 amino acids |
| Related rules |
None |
| Fusion | Nter: None Cter: None |
| Comments | Found in almost all CRISPR systems. In Bacillus halodurans and Thermus thermophilus is a dsDNase. |