HAMAP rule MF_01486

General rule information [?]

Accession	MF_01486
Dates	16-DEC-2013 (Created) 10-NOV-2023 (Last updated, Version 16)
Name	RecC
Scope(s)	Bacteria Actinomycetota Bacteroidota Chlamydiota Chlorobiota Deferribacteres Pseudomonadota Spirochaetota
Template(s)	P07648 (RECC_ECOLI); [ Recover all ]
Triggered by	HAMAP; MF_01486 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier	RECC
RecName: Full=RecBCD enzyme subunit RecC;<br /> AltName: Full=Exonuclease V subunit RecC;<br />                  Short=ExoV subunit RecC;<br /> AltName: Full=Helicase/nuclease RecBCD subunit RecC;
Gene name	Name=recC;

Comments [?]

FUNCTION	A helicase/nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild-type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity.
SUBUNIT	Heterotrimer of RecB, RecC and RecD. All subunits contribute to DNA-binding.
MISCELLANEOUS	In the RecBCD complex, RecB has a slow 3'-5' helicase, an exonuclease activity and loads RecA onto ssDNA, RecD has a fast 5'- 3' helicase activity, while RecC stimulates the ATPase and processivity of the RecB helicase and contributes to recognition of the Chi site.
SIMILARITY	Belongs to the RecC family.

Keywords [?]

ATP-binding
DNA damage
DNA repair
DNA-binding
Exonuclease
<a href="https://www.uniprot.org/keywords/KW-0347">Helicase</a>
Hydrolase
Nuclease
Nucleotide-binding

Gene Ontology [?]

GO:0003678; Molecular function:DNA helicase activity

GO:0005524; Molecular function:ATP binding

GO:0003677; Molecular function:DNA binding

GO:0000724; Biological process:double-strand break repair via homologous recombination

Cross-references [?]

Features [?]

Additional information [?]