HAMAP

Accession	MF_01510
Dates	11-FEB-2004 (Created) 2-DEC-2011 (Last updated, Version 18)

Data class

Protein

Predictors

HAMAP; MF_01510; [distribution of match scores in UniProtKB];[seed alignment for MF_01510]

Names

GMP_synthase_A

Identifier

GUAAA

Protein name

RecName: Full=GMP synthase [glutamine-hydrolyzing] subunit A; EC=6.3.5.2; AltName: Full=Glutamine amidotransferase;

Gene name

guaAA

FUNCTION: Catalyzes the synthesis of GMP from XMP (By similarity).

CATALYTIC ACTIVITY: ATP + xanthosine 5'-phosphate + L-glutamine + H(2)O = AMP + diphosphate + GMP + L-glutamate.

PATHWAY: Purine metabolism; GMP biosynthesis; GMP from XMP (L-Gln route): step 1/1.

SUBUNIT: Heterodimer composed of a glutamine amidotransferase subunit (A) and a GMP-binding subunit (B) (Potential).

SIMILARITY: Contains 1 glutamine amidotransferase type-1 domain.

Pfam	PF00117; GATase; 1;
PRINTS	PR00096; GATASE; 1;
TIGRFAMs	TIGR00888; GuaA_Nterm; 1;
PROSITE	PS51273; GATASE_TYPE_1; 1; trigger=PRU00605;

ATP-binding, GMP biosynthesis, Glutamine amidotransferase, Ligase, Nucleotide-binding, Purine biosynthesis.

GO:0003922; Molecular function: GMP synthase (glutamine-hydrolyzing) activity.
GO:0006177; Biological process: GMP biosynthetic process.

From: GUAAA_METJA (Q58970)
Key		From		To		Description		Condition		FTGroup
ACT_SITE		76		76		Nucleophile (By similarity)		C
ACT_SITE		163		163		By similarity		H
ACT_SITE		165		165		By similarity		E

Size range:	181-202 amino acids
Related UniRules:	MF_00344 (GUAA (supersedes the current rule))
Template:	P04079 (GUAA_ECOLI)
Scope:	Archaea
Fusion:	Nter: None; Cter: None
Duplicate:	None
Plasmid encoded:	None
Comments:	Sequences from AERPE and PYRAE are like that of Eubacteria composed of two domains, while other archaea have separate proteins that correspond to each domain