Annotation rule MF_01510
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General rule information [?]

Accession MF_01510
Dates 11-FEB-2004 (Created)
13-JUN-2013 (Last updated, Version 19)
Name GMP_synthase_A
Scope Archaea

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
GUAAA
Protein name
RecName: Full=GMP synthase [glutamine-hydrolyzing] subunit A;
EC=6.3.5.2;
AltName: Full=Glutamine amidotransferase;
Gene name
guaAA

Comments [?]

Function Catalyzes the synthesis of GMP from XMP (By similarity).
Catalytic activity ATP + XMP + L-glutamine + H(2)O = AMP + diphosphate + GMP + L-glutamate.
Pathway Purine metabolism; GMP biosynthesis; GMP from XMP (L-Gln route); step 1/1.
Subunit Heterodimer composed of a glutamine amidotransferase subunit (A) and a GMP-binding subunit (B) (Potential).
case <Feature:PS51273>
Similarity Contains 1 glutamine amidotransferase type-1 domain.
end case

Keywords [?]


Gene Ontology [?]

GO:0003922; Molecular function: GMP synthase (glutamine-hydrolyzing) activity.
GO:0006177; Biological process: GMP biosynthetic process.

Cross-references [?]

Pfam PF00117; GATase; 1;
PRINTS PR00096; GATASE; 1;
TIGRFAMs TIGR00888; GuaA_Nterm; 1;
PROSITE PS51273; GATASE_TYPE_1; 1; trigger=PRU00605;

Features [?]

From: GUAAA_METJA (Q58970)
Key     From     To       Description   Tag   Condition   FTGroup
ACT_SITE     76     76       Nucleophile (By similarity)     C  
ACT_SITE     163     163       By similarity     H  
ACT_SITE     165     165       By similarity     E  

Additional information [?]

Size range 181-202 amino acids
Related rules MF_00344 (GUAA supersedes the current rule)
Template P04079 (GUAA_ECOLI)
Fusion None
Comments Sequences from AERPE and PYRAE are like that of Eubacteria composed of two domains, while other archaea have separate proteins that correspond to each domain