Annotation rule MF_01510
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General rule information [?]

Accession MF_01510
Dates 11-FEB-2004 (Created)
13-JUN-2013 (Last updated, Version 19)
Name GMP_synthase_A
Scope Archaea
Template P04079 (GUAA_ECOLI)

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
GUAAA
Protein name
RecName: Full=GMP synthase [glutamine-hydrolyzing] subunit A;
EC=6.3.5.2;
AltName: Full=Glutamine amidotransferase;
Gene name
guaAA

Comments [?]

Function Catalyzes the synthesis of GMP from XMP (By similarity).
Catalytic activity ATP + XMP + L-glutamine + H(2)O = AMP + diphosphate + GMP + L-glutamate.
Pathway Purine metabolism; GMP biosynthesis; GMP from XMP (L-Gln route); step 1/1.
Subunit Heterodimer composed of a glutamine amidotransferase subunit (A) and a GMP-binding subunit (B) (Potential).
case <Feature:PS51273>
Similarity Contains 1 glutamine amidotransferase type-1 domain.
end case

Keywords [?]


Gene Ontology [?]

GO:0003922; Molecular function: GMP synthase (glutamine-hydrolyzing) activity.
GO:0006177; Biological process: GMP biosynthetic process.

Cross-references [?]

Pfam PF00117; GATase; 1;
PRINTS PR00096; GATASE; 1;
TIGRFAMs TIGR00888; GuaA_Nterm; 1;
PROSITE PS51273; GATASE_TYPE_1; 1; trigger=PRU00605;

Features [?]

From: GUAAA_METJA (Q58970)
Key     From     To       Description   Tag   Condition   FTGroup
ACT_SITE     76     76       Nucleophile (By similarity)     C  
ACT_SITE     163     163       By similarity     H  
ACT_SITE     165     165       By similarity     E  

Additional information [?]

Size range 181-202 amino acids
Related rules MF_00344 (GUAA supersedes the current rule)
Fusion None
Comments Sequences from AERPE and PYRAE are like that of Eubacteria composed of two domains, while other archaea have separate proteins that correspond to each domain