Due to maintenance work, this service will not be available Thursday August 21st between 7am and 8am CEST.
Annotation rule MF_01511
Send feedback

General rule information [?]

Accession MF_01511
Dates 17-FEB-2004 (Created)
17-FEB-2010 (Last updated, Version 12)
Name GMP_reduct_type2
Scope Bacteria; Firmicutes
Bacteria; Betaproteobacteria
Bacteria; Campylobacterales

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
GUAC
Protein name
RecName: Full=GMP reductase;
EC=1.7.1.7;
AltName: Full=Guanosine 5'-monophosphate oxidoreductase;
Short=Guanosine monophosphate reductase;
Gene name
guaC

Comments [?]

Function Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides (By similarity).
Catalytic activity Inosine 5'-phosphate + NH(3) + NADP(+) = guanosine 5'-phosphate + NADPH.
Similarity Belongs to the IMPDH/GMPR family. GuaC type 2 subfamily.

Keywords [?]


Gene Ontology [?]

GO:0003920; Molecular function: GMP reductase activity.
GO:0006163; Biological process: purine nucleotide metabolic process.

Cross-references [?]

Pfam PF00478; IMPDH; 1;
TIGRFAMs TIGR01306; GMP_reduct_2; 1;
PROSITE PS00487; IMP_DH_GMP_RED; 1;

Features [?]

From: GUAC_BACSU (O05269)
Key     From     To       Description   Tag   Condition   FTGroup
NP_BIND     204     227       NADP (Potential)        
ACT_SITE     175     175       Thioimidate intermediate (By similarity)     C  

Additional information [?]

Size range 316-330 amino acids
Related rules None
Template O05269 (GUAC_BACSU)
Fusion None