HAMAP rule MF_01511
General rule information
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Accession | MF_01511 |
Dates | 17-FEB-2004 (Created)
1-JUN-2023 (Last updated, Version 19) |
Name | GMP_reduct_type2 |
Scope(s) |
Bacteria Bacillota Betaproteobacteria Campylobacterales |
Template(s) | O05269 (GUAC_BACSU); [ Recover all ] |
Triggered by |
HAMAP; MF_01511 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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Identifier | GUAC |
Protein name | RecName: Full=GMP reductase; EC=1.7.1.7; AltName: Full=Guanosine 5'-monophosphate oxidoreductase; Short=Guanosine monophosphate reductase; |
Gene name | Name=guaC; |
Comments
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FUNCTION | Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides. |
CATALYTIC ACTIVITY | Reaction=IMP + NADP(+) + NH4(+) = GMP + 2 H(+) + NADPH; Xref=Rhea:RHEA:17185, ChEBI:CHEBI:15378, ChEBI:CHEBI:28938, ChEBI:CHEBI:57783, ChEBI:CHEBI:58053, ChEBI:CHEBI:58115, ChEBI:CHEBI:58349; EC=1.7.1.7; |
SIMILARITY | Belongs to the IMPDH/GMPR family. GuaC type 2 subfamily. |
Keywords
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Gene Ontology
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GO:0003920; Molecular function:GMP reductase activity |
GO:0006163; Biological process:purine nucleotide metabolic process |
Cross-references
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Features
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From: GUAC_BACSU (O05269) | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
BINDING | 204 | 227 | /ligand="NADP(+)" /ligand_id="ChEBI:CHEBI:58349" |
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ACT_SITE | 175 | 175 | /note="Thioimidate intermediate" | C |
Additional information
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Size range | 316-330 amino acids |
Related rules |
None |
Fusion | Nter: None Cter: None |