HAMAP

Accession	MF_01512
Dates	29-MAR-2004 (Created) 2-DEC-2011 (Last updated, Version 14)

Data class

Protein

Predictors

HAMAP; MF_01512; [distribution of match scores in UniProtKB];[seed alignment for MF_01512]

Names

FosB

Identifier

FOSB

Protein name

RecName: Full=Metallothiol transferase fosB; EC=2.5.1.-; AltName: Full=Fosfomycin resistance protein;

Gene name

fosB

FUNCTION: Metallothiol transferase which confers resistance to fosfomycin by catalyzing the addition of a thiol cofactor to fosfomycin. L-cysteine is probably the physiological thiol donor (By similarity).

COFACTOR: Magnesium (By similarity).

SUBUNIT: Homodimer (By similarity).

SUBCELLULAR LOCATION: Cytoplasm (By similarity).

SIMILARITY: Belongs to the fosfomycin resistance protein family. FosB subfamily.

Pfam	PF00903; Glyoxalase; 1;

Cytoplasm, Transferase.

Magnesium, Metal-binding.

Antibiotic resistance.

GO:0000287; Molecular function: magnesium ion binding.

GO:0016765; Molecular function: transferase activity, transferring alkyl or aryl (other than methyl) groups.
GO:0046677; Biological process: response to antibiotic.
GO:0005737; Cellular component: cytoplasm.

From: FOSB_BACSU (O31817)
Key		From		To		Description		Condition		FTGroup
METAL		8		8		Magnesium (By similarity)		H		1
METAL		67		67		Magnesium (By similarity)		H		1
METAL		116		116		Magnesium (By similarity)		E		1

Size range:	138-154 amino acids
Related UniRules:	None
Template:	O31817 (FOSB_BACSU); Q03377 (FOSB_STAEP); Q56415 (FOSA_SERMA): [Recover all]
Scope:	Bacteria; Bacillales
Fusion:	Nter: None; Cter: None
Duplicate:	in BACAN
Plasmid encoded:	in STAES, STAHA, STAHJ